Results 71 to 80 of about 19,829 (313)

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation.

Journal of the American Chemical Society, 2021
The targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current proteolysis-targeting chimera (PROTAC) methodology.
Heng Zhang, Yu Han, Yuanfan Yang, Fen-chun Lin, Kexin Li, Linghao Kong, Hongxiang Liu, Yongjun Dang, Jian Lin, Peng R. Chen   +9 more
semanticscholar   +1 more source

Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV

Nat. Mac. Intell.
Monoclonal antibodies have emerged as key therapeutics. In particular, nanobodies, small, single-domain antibodies that are naturally expressed in camelids, are rapidly gaining momentum following the approval of the first nanobody drug in 2019 ...
Aubin Ramon, Montader Ali, Misha Atkinson, Alessio Saturnino, Kieran Didi, Cristina Visentin, Stefano Ricagno, Xing Xu, M. Greenig, P. Sormanni   +9 more
semanticscholar   +1 more source

Ozoralizumab, a Humanized Anti-TNFα NANOBODY® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

Frontiers in Immunology, 2022
Although the introduction of tumor necrosis factor (TNF) inhibitors represented a significant advance in the treatment of rheumatoid arthritis (RA), traditional anti-TNFα antibodies are somewhat immunogenic, and their use results in the formation of anti-
Chihiro Ishiwatari-Ogata, Masanao Kyuuma, Hitoshi Ogata, Machi Yamakawa, K. Iwata, Motoki Ochi, Miyuki Hori, N. Miyata, Yasuyuki Fujii   +8 more
semanticscholar   +1 more source

Institute collection and analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies [PDF]

BMC Genomics, 2017
Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae. As a novel class of antibody, they show many advantages compared with traditional antibodies such as smaller size, higher stability, improved specificity, more easily expressed in microorganisms.
Jing Zuo, Jian Li, Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie   +9 more
openaire   +4 more sources

Anti-CTLA-4 nanobody as a promising approach in cancer immunotherapy

Cell Death and Disease
Cancer is one of the most common diseases and causes of death worldwide. Since common treatment approaches do not yield acceptable results in many patients, developing innovative strategies for effective treatment is necessary.
Mehregan Babamohamadi, Nastaran Mohammadi, Elham Faryadi, Maryam Haddadi, Amirhossein Merati, Farbod Ghobadinezhad, Roshanak Amirian, Z. Izadi, J. Hadjati   +8 more
semanticscholar   +1 more source

Superimmunity by pan-sarbecovirus nanobodies

Cell Reports, 2022
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies with improved potency and breadth. Here, we observe superimmunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain (RBD). We rapidly isolate a large repertoire of specific ultra-high-affinity nanobodies that bind strongly to all known ...
Yufei Xiang, Wei Huang, Hejun Liu, Zhe Sang, Sham Nambulli, Jérôme Tubiana, Kevin L. Williams, W. Paul Duprex, Dina Schneidman-Duhovny, Ian A. Wilson, Derek J. Taylor, Yi Shi   +11 more
openaire   +2 more sources

Nanobodies—Useful Tools for Allergy Treatment? [PDF]

Frontiers in Immunology, 2020
In the last decade single domain antibodies (nanobodies, VHH) qualified through their unique characteristics have emerged as accepted and even advantageous alternative to conventional antibodies and have shown great potential as diagnostic and therapeutic tools. Currently nanobodies find their main medical application area in the fields of oncology and
Sergei Tillib, Sabine Flicker, Ines Zettl   +2 more
openaire   +4 more sources

Development of nanobody-horseradish peroxidase-based sandwich ELISA to detect Salmonella Enteritidis in milk and in vivo colonization in chicken

Journal of Nanobiotechnology, 2022
Background Salmonella Enteritidis ( S. Enteritidis ) being one of the most prevalent foodborne pathogens worldwide poses a serious threat to public safety.
Kui Gu, Zengxu Song, Changyu Zhou, Peng Ma, Chao Li, Qizhong Lu, Ziwei Liao, Zheren Huang, Yizhi Tang, Hao Li, Yu Zhao, Wenjun Yan, Changwei Lei, Hongning Wang   +13 more
semanticscholar   +1 more source

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Biomaterials Research, 2022
Background It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades.
Jingbo Ma, Xiaolong Xu, Chunjin Fu, Peng Xia, Ming Tian, Liuhai Zheng, Kun Chen, Xiaolian Liu, Yilei Li, Le Yu, Qinchang Zhu, Yangyang Yu, Rongrong Fan, Haibo Jiang, Zhifen Li, Chuanbin Yang, Chengchao Xu, Ying Long, Jigang Wang, Zhijie Li   +19 more
doaj   +1 more source

A highly specific gold nanoprobe for live-cell single-molecule imaging [PDF]

, 2013
Single molecule tracking in live cells is the ultimate tool to study subcellular protein dynamics, but it is often limited by the probe size and photostability. Due to these issues, long-term tracking of proteins in confined and crowded environments, such as intracellular spaces, remains challenging.
arxiv   +1 more source