Results 61 to 70 of about 743,554 (284)
Graphene Nanopores for Protein Sequencing [PDF]
Biophysical Journal, 2016 An inexpensive, reliable method for protein sequencing is essential to unraveling the biological mechanisms governing cellular behavior and disease. Current protein sequencing methods suffer from limitations associated with the size of proteins that can be sequenced, the time, and the cost of the sequencing procedures. This study reports the results of
Wilson, James +3 more
openaire +3 more sources
Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos +5 more
wiley +1 more source
BMC Pulmonary Medicine, 2023 Background To determine the diagnostic accuracy of a nanopore sequencing assay of PCR products from a M. tuberculosis complex-specific region for testing of bronchoalveolar lavage fluid (BALF) samples or sputum samples from suspected pulmonary ...
Zhifeng Liu +5 more
doaj +1 more source
Frontiers in Public Health, 2021 Fast and accurate identification of pathogens is an essential task in healthcare settings. Second-generation sequencing platforms such as Illumina have greatly expanded the capacity with which different organisms can be detected in hospital samples, and ...
Guilherme Marcelino Viana de Siqueira +3 more
doaj +1 more source
Error-Correcting Codes for Nanopore Sequencing
2023 IEEE International Symposium on Information Theory (ISIT), 2023 Submitted to Transactions on Information ...
Anisha Banerjee +3 more
openaire +5 more sources
Application of Oxford Nanopore sequencing for the study of marine biodiversity
, 2023 reservedIl sequenziamento Oxford Nanopore ha permesso negli ultimi anni di migliorare le analisi metagenomiche, rendendo possibile l’identificazione di informazioni genetiche rilevanti dove le short reads avevano precedentemente fallito. In questo studio
CALLEGARO, ANDREA
core
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan +7 more
wiley +1 more source
cgMSI: pathogen detection within species from nanopore metagenomic sequencing data
BMC Bioinformatics, 2023 Background Metagenomic sequencing is an unbiased approach that can potentially detect all the known and unidentified strains in pathogen detection. Recently, nanopore sequencing has been emerging as a highly potential tool for rapid pathogen detection ...
Xu Zhu +5 more
doaj +1 more source
Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo
Advanced Functional Materials, EarlyView.In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim +28 more
wiley +1 more source
Shengwu huaxue yu shengwu wuli jinzhanThe success of the Human Genome Project has significantly deepened our understanding of genomics and catalyzed a growing focus on proteomics, as researchers aim to decipher the complex relationship between genes and proteins.
LI Zi-Yi +3 more
doaj +1 more source