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Uterine Natural Killer Cells [PDF]
Frontiers in Immunology, 2019 Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK ...
Dorothy K. Sojka +2 more
doaj +5 more sources
Natural killer cells in antitumour adoptive cell immunotherapy
Nature Reviews Cancer, 2022 Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally infected cells and tumour cells.
Alexander Biederstädt
exaly +2 more sources
Natural killer cells in antiviral immunity
Nature Reviews Immunology, 2021 Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.
Niklas K Björkström +2 more
exaly +2 more sources
Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors [PDF]
Molecular Therapy: OncologyAlthough adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell trafficking and ...
Shiori Eguchi +5 more
doaj +2 more sources
SnapShot: Natural Killer Cells
Cell, 2020 NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising ...
Adeline Crinier +3 more
semanticscholar +4 more sources
Targeting natural killer cells and natural killer T cells in cancer [PDF]
Nature Reviews Immunology, 2012 Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on
Eric Vivier +2 more
exaly +4 more sources
Natural killer cells in multiple sclerosis: foe or friends? [PDF]
Frontiers in Cellular NeuroscienceMultiple sclerosis (MS) is an immune-mediated disorder involving the central nervous system (CNS), in which demyelination is caused. The initiation and progression of MS is thought to depend largely on CD4+ T lymphocytes, yet new data has emphasized the ...
Fatemeh Aghaee +5 more
doaj +2 more sources
Adaptive immune features of natural killer cells
Nature, 2009 In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen.
Joseph C Sun, Lewis L Lanier
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NatureNatural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance
Eric Vivier +5 more
semanticscholar +4 more sources
Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders
Nature Reviews Drug Discovery, 2022 Nicholas A Maskalenko +2 more
exaly +2 more sources