Uterine Natural Killer Cells [PDF]
Frontiers in Immunology, 2019 Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK ...
Dorothy K. Sojka +2 more
doaj +5 more sources
Natural killer cells in multiple sclerosis: foe or friends? [PDF]
Frontiers in Cellular NeuroscienceMultiple sclerosis (MS) is an immune-mediated disorder involving the central nervous system (CNS), in which demyelination is caused. The initiation and progression of MS is thought to depend largely on CD4+ T lymphocytes, yet new data has emphasized the ...
Fatemeh Aghaee +5 more
doaj +2 more sources
Reduced proportion and activity of natural killer cells in patients with Graves’ disease
European Journal of Inflammation, 2020 Natural killer cells not only play important roles in protecting against viral infection and cancer but also involved in the pathogenesis of Graves’ disease.
Qingqing Yang +6 more
doaj +1 more source
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. [PDF]
PLoS ONE, 2014 Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated the molecular mechanisms underlying the enhancement of natural
Vu T A Dang +7 more
doaj +1 more source
Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy [PDF]
Einstein (São Paulo)Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with ...
Júlia Teixeira Cottas de Azevedo +11 more
doaj +1 more source
Natural killer cell in the development and treatment of head and neck squamous cell carcinoma [PDF]
Yixue xinzhi zazhi, 2021 Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors in the world. It has a high metastasis rate and a poor prognosis.
Lu-Ming WANG, Shang XIE
doaj +1 more source
BMC Immunology, 2019 Background Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors.
Alexandra Tremblay-McLean +4 more
doaj +1 more source
Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling
Frontiers in Immunology, 2022 Cancer immunotherapy uses the immune system to achieve therapeutic effects; however, its effect is still limited. Therefore, in addition to immune checkpoint-based treatment, the development of other strategies that can inhibit cancer cells from ...
Jei-Ming Peng +8 more
doaj +1 more source
In vivo generation of decidual natural killer cells from resident hematopoietic progenitors
Haematologica, 2014 Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown.
Laura Chiossone +9 more
doaj +1 more source
Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
Haematologica, 2016 Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri +10 more
doaj +1 more source