Results 1 to 10 of about 664,837 (368)
Natural Killer Cells in Asthma [PDF]
Frontiers in Immunology, 2013 The worldwide prevalence, morbidity, and mortality of asthma have dramatically increased over the last few decades and there is a clear need to identify new effective therapeutic and prophylactic strategies. Despite high numbers of NK cells in the lung and their ability to generate a variety of immunomodulatory mediators, the potential of NK cells as ...
Khalil Karimi, Paul Forsythe
doaj +13 more sources
Natural killer cells and natural killer T cells in Lyme arthritis [PDF]
Arthritis Research & Therapy, 2013 Abstract Introduction Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation. Lyme arthritis usually resolves with antibiotic treatment.
Allen C. Steere +3 more
openaire +8 more sources
Uterine Natural Killer Cells [PDF]
Frontiers in Immunology, 2019 Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK (trNK) cells in many tissues that resemble group 1 ILCs (ILC1s).
Sojka, Dorothy K +2 more
openaire +6 more sources
Targeting natural killer cells and natural killer T cells in cancer [PDF]
Nature Reviews Immunology, 2012 Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on
Eric Vivier +2 more
exaly +5 more sources
Natural killer and natural killer T cells in liver fibrosis [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Svetlana Radaeva, Bin Gao
openaire +4 more sources
Natural Killer Cell Memory [PDF]
Immunity, 2015 Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of
Joseph C. Sun +3 more
openaire +5 more sources
Current Biology, 1999 Perhaps, but probably not a long or healthy life. There is only one documented human case of an absolute NK cell deficiency, which was associated with recurrent life-threatening bacterial and viral infections.
openaire +3 more sources
SnapShot: Natural Killer Cells
Cell, 2020 NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising ...
Crinier, Adeline +3 more
openaire +4 more sources
The trafficking of natural killer cells [PDF]
Immunological Reviews, 2007 Summary: Natural killer (NK) cells are large granular lymphocytes of the innate immune system that participate in the early control of microbial infections and cancer. NK cells can induce the death of autologous cells undergoing various forms of stress, recognizing and providing non‐microbial ‘danger’ signals to the immune system.
Frederic Geissmann +10 more
openaire +4 more sources
Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury [PDF]
International Journal of Molecular Sciences, 2019 Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident.
Takahiro Uchida +6 more
openaire +3 more sources