Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors [PDF]
Molecular Therapy: OncologyAlthough adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell trafficking and ...
Shiori Eguchi +5 more
doaj +2 more sources
Natural Killer Cells in Asthma [PDF]
Frontiers in Immunology, 2013 The worldwide prevalence, morbidity, and mortality of asthma have dramatically increased over the last few decades and there is a clear need to identify new, effective, therapeutic and prophylactic strategies. Despite high numbers of NK cells in the lung
Khalil eKarimi, Paul eForsythe
doaj +3 more sources
Natural killer cells in multiple sclerosis: foe or friends? [PDF]
Frontiers in Cellular NeuroscienceMultiple sclerosis (MS) is an immune-mediated disorder involving the central nervous system (CNS), in which demyelination is caused. The initiation and progression of MS is thought to depend largely on CD4+ T lymphocytes, yet new data has emphasized the ...
Fatemeh Aghaee +5 more
doaj +2 more sources
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. [PDF]
PLoS ONE, 2014 Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated the molecular mechanisms underlying the enhancement of natural
Vu T A Dang +7 more
doaj +1 more source
Reduced proportion and activity of natural killer cells in patients with Graves’ disease
European Journal of Inflammation, 2020 Natural killer cells not only play important roles in protecting against viral infection and cancer but also involved in the pathogenesis of Graves’ disease.
Qingqing Yang +6 more
doaj +1 more source
Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy [PDF]
Einstein (São Paulo)Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with ...
Júlia Teixeira Cottas de Azevedo +11 more
doaj +1 more source
Natural killer cell in the development and treatment of head and neck squamous cell carcinoma [PDF]
Yixue xinzhi zazhi, 2021 Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors in the world. It has a high metastasis rate and a poor prognosis.
Lu-Ming WANG, Shang XIE
doaj +1 more source
BMC Immunology, 2019 Background Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors.
Alexandra Tremblay-McLean +4 more
doaj +1 more source
Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling
Frontiers in Immunology, 2022 Cancer immunotherapy uses the immune system to achieve therapeutic effects; however, its effect is still limited. Therefore, in addition to immune checkpoint-based treatment, the development of other strategies that can inhibit cancer cells from ...
Jei-Ming Peng +8 more
doaj +1 more source
Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]
, 2012 Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Bower, Mark +5 more
core +1 more source