Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients [PDF]
Haematologica, 2015 We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile +7 more
doaj +5 more sources
Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C [PDF]
Brazilian Journal of Infectious DiseasesNatural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors.
Amal Fathy +5 more
doaj +2 more sources
Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]
Frontiers in Immunology, 2015 Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Gianfranco ePittari +4 more
doaj +3 more sources
Control of human cytomegalovirus replication by liver resident natural killer cells [PDF]
, 2023 Natural killer cells are considered to be important for control of human cytomegalovirus– a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells ...
Chase, T +9 more
core +4 more sources
Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy. [PDF]
Einstein (Sao Paulo)Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with ...
Azevedo JTC +11 more
europepmc +3 more sources
Algorithmic asymptotic analysis: extending the arsenal of cancer immunology modeling [PDF]
Journal of Theoretical Biology Volume 534, 7 February 2022, 110975, 2021 The recent advances in cancer immunotherapy boosted the development of tumor-immune system models aiming to provide mechanistic understanding and indicate more efficient treatment regimes. However, the complexity of such models, their multi-scale dynamics and their overparameterized character renders them inaccessible for wide utilization. In this work,
arxiv +1 more source
Benralizumab affects NK cell maturation and proliferation in severe asthmatic patients [PDF]
, 2023 Introduction: The mechanism of action of benralizumab is determined by its afucosylated constant fragment that binds CD16a receptors on the membrane of natural killer cells.
Bargagli, Elena +5 more
core +1 more source
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. [PDF]
PLoS ONE, 2014 Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated the molecular mechanisms underlying the enhancement of natural
Vu T A Dang +7 more
doaj +1 more source
Reduced proportion and activity of natural killer cells in patients with Graves’ disease
European Journal of Inflammation, 2020 Natural killer cells not only play important roles in protecting against viral infection and cancer but also involved in the pathogenesis of Graves’ disease.
Qingqing Yang +6 more
doaj +1 more source