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The trafficking of natural killer cells [PDF]
Immunological Reviews, 2007 Summary: Natural killer (NK) cells are large granular lymphocytes of the innate immune system that participate in the early control of microbial infections and cancer. NK cells can induce the death of autologous cells undergoing various forms of stress, recognizing and providing non‐microbial ‘danger’ signals to the immune system.
Frederic Geissmann +10 more
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Haematologica, 2015 We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile +7 more
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Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury [PDF]
International Journal of Molecular Sciences, 2019 Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident.
Takahiro Uchida +6 more
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Natural killer cell-mediated immunopathology in recurrent pregnancy losses
Exploration of Immunology, 2022 Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine NK (uNK) cells dynamically change their proportions and ...
Thanh Luu +7 more
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Natural killer and natural killer T cells in liver fibrosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Svetlana Radaeva, Bin Gao
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, 2014 Natural killer (NK) cells are lymphocytes of the innate immune system. From a functional point of view, they have been well characterized for their ability to control tumors and infections. However, more recent data indicate that NK cells may also play an important immunoregulatory role.
Yenan T. Bryceson +3 more
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Nature Communications, 2022 Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam +12 more
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Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
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Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro
Frontiers in Immunology, 2023 ObjectiveNatural killer (NK) cells are a part of the innate immune system and first-line defense against cancer. Since they possess natural mechanisms to recognize and kill tumor cells, NK cells are considered as a potential option for an off-the-shelf ...
Minna Sivonen +9 more
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Highly activated and expanded natural killer cells for multiple myeloma immunotherapy
Haematologica, 2012 Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg +19 more
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