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Therapeutic Applications: Natural Killer Cells [PDF]
Journal of Clinical and Diagnostic Research, 2018 Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in ...
Preeti Sharma +2 more
doaj +1 more source
Dynamics of Natural Killer cell receptor revealed by quantitative analysis of photoswitchable protein [PDF]
Biophysical Journal, Volume 105, 1-10, (2013), 2013 Natural Killer (NK) cell activation is dynamically regulated by numerous activating and inhibitory surface receptors that accumulate at the immune synapse. Quantitative analysis of receptor dynamics has been limited by methodologies which rely on indirect measurements such as fluorescence recovery after photobleaching.
arxiv +1 more source
Stochastic model of T Cell repolarization during target elimination (II) [PDF]
, 2021 Cytotoxic T lymphocytes (T cells) and natural killer cells form a tight contact, the immunological synapse (IS), with target cells, where they release their lytic granules containing perforin/granzyme and cytokine containing vesicles. During this process the cell repolarizes and moves the microtubule organizing center (MTOC) towards the IS.
arxiv +1 more source
A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread [PDF]
, 2012 The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic spread unless dissemination is blocked in the lymph node itself.
Germain, R. +4 more
core +1 more source
Haematologica, 2009 Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang +7 more
doaj +1 more source
PLoS ONE, 2019 Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka +12 more
doaj +1 more source
Stochastic model of T Cell repolarization during target elimination (I) [PDF]
, 2020 Cytotoxic T lymphocytes (T) and natural killer (NK) cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e. target cells). Once a NK or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS).
arxiv +1 more source
Signal processing in slit-scan flow cytometry of cell conjugates [PDF]
, 1993 The design and implementation of a real-time signal processing system for slit-scan flow cytometry is described. The system is used to measure the separate scatter and fluorescence peak heights of 2 adherent cells.
Bakker Schut +9 more
core +2 more sources
Exploring The Contribution of Innate Immune Cells to Breast Cancer Immunotherapy [PDF]
arXiv, 2023 Breast cancer is the leading type of cancer in women. About 10-15% of breast cancers are triple-negative breast cancer (TNBC), a subtype with the worst prognosis. Due to the lack of estrogen, progesterone and HER2 receptor expression, chemotherapies have been the standard of care for decades.
arxiv
The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer cells represents a therapeutic target in haploidentical haematopoietic stem cell transplantation [PDF]
, 2018 Natural Killer cells are the first lymphocyte population to reconstitute early after non myelo-ablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide.
Bicciato, Silvio +19 more
core +4 more sources