Results 101 to 110 of about 226,818 (311)

Natural Killer cells responsiveness to physical esercise: a brief review [PDF]

, 2013
Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A., CRISAFULLI, ANTONIO, Melis F, MILIA, RAFFAELE, TOCCO, FILIPPO   +4 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Natural killer cells in multiple sclerosis: foe or friends?

Frontiers in Cellular Neuroscience
Multiple sclerosis (MS) is an immune-mediated disorder involving the central nervous system (CNS), in which demyelination is caused. The initiation and progression of MS is thought to depend largely on CD4+ T lymphocytes, yet new data has emphasized the ...
Fatemeh Aghaee, Mohammadreza Abedinpour, Saeid Anvari, Alia Saberi, Amir Fallah, Arash Bakhshi   +5 more
doaj   +1 more source

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Alonso, Corona, Arcos, María José, Bañas, Helena, Bergua, Juan M., Casas-Avilés, Ignacio, Durán, Esther, Hassouneh, Fakhri, López-Sejas, Nelson, Pera Rojas, Alejandra, Solana, Rafael, Sánchez-Correa, Beatriz, Tarazona, Raquel, Valhondo, Isabel   +12 more
core   +1 more source

Assays of Natural Killer (NK) Cell Ligation to Target Cells

Current Protocols in Cytometry, 1998
AbstractAssays for natural killer cells have long been established in the flow repertoire, but successful application of a flow‐based protocol requires attention to many details. This unit provides these details in a comprehensive manner. In particular, the assay is designed for simple bench‐top cytometers, rather than for more complex research ...
RENO' F, PAPA, STEFANO, VITALE M, ZAMAI, LORIS   +3 more
openaire   +5 more sources

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Ly49 receptors: Innate and adaptive immune paradigms

Frontiers in Immunology, 2014
The Ly49 receptors are type II C-type lectin-like membrane glycoproteins encoded by a family of highly polymorphic and polygenic genes within the mouse natural killer gene complex (NKC). This gene family is designated Klra, and includes genes that encode
Mir Munir A Rahim, Megan M Tu, Ahmad Bakur Mahmoud, Andrew eWight, Elias eAbou-Samra, Patricia D. A. Lima, Andrew P Makrigiannis   +6 more
doaj   +1 more source

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells [PDF]

, 2016
Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of
Villarino, Alejandro V^, Sciumè, Giuseppe^, Davis, Fred P, Iwata, Shigeru, Zitti, Beatrice, Robinson, Gertraud W, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J, ^Co-Firs, T.   +9 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source