Results 81 to 90 of about 226,818 (311)

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Environmental stimuli shape microglial plasticity in glioma [PDF]

, 2017
In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, contributing to tumor growth and maintaining a pro-tumorigenic, immunosuppressed microenvironment.
Alboni, Armaiz-Pena, Bisht, Branchi, Butovsky, Cao, Chabry, Coniglio, Coughlin, Duluc, Dunn, Ehninger, Ehninger, Gabrusiewicz, Garofalo, Goldszmid, Graeber, Guillerey, Hambardzumyan, Haynes, Jung, Kaplan, Kmiecik, Kmiecik, Koka, Lauro, Mantovani, Markovic, Markovic, Mathios, Mieczkowski, Morrison, Murray, Nachat-Kappes, Nguyen, Ohsawa, Pagani, Parker, Pyonteck, Quail, Rattazzi, Richter, Rodríguez, Sale, Schmittgen, Sica, Sierra, Song, Stabile, Strengell, Szulzewsky, Szulzewsky, Tremblay, Tremblay, Van Rooijen, Vivier, Waldmann, Westwood, Yu, Zhu   +59 more
core   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Identification of new populations of chicken natural killer (NK) cells [PDF]

, 2010
Natural killer (NK) cell activity is conserved throughout vertebrate development, but characterization of non-mammalian NK-cells has been hampered by the absence of specific mAbs for these cells.Monoclonal antibodies were generated against in vitro IL-2 ...
de Wit, Sjaak, Goebel, Thomas W., Jansen, Christine A., van de Haar, Peter M., van Eden, Willem, van Haarlem, Daphne, van Kooten, Peter, Vervelde, Lonneke, Viertlboeck, Birgit C.   +8 more
core   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Natural Killer Cells in Cancers of Respiratory System and Their Applications in Therapeutic Approaches

Immunity, Inflammation and Disease
Background Cancer is still regarded as a major worldwide health issue due to its high health and socioeconomic burden. Currently, lung cancer is the most common cause of cancer‐related fatalities globally. Additionally, mesotheliomas and other cancers of
Maryam Dokhanchi, Atefe Panahipoor Javaherdehi, Mohammad Raad, Shayan Khalilollah, Pooya Mahdavi, Mohammad Hossein Razizadeh, Alireza Zafarani   +6 more
doaj   +1 more source

Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

Nature Communications, 2019
Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103+Eomes+ NK cells are the predominant ILC population, but are replaced gradually by ...
Adrian F. Sagebiel, Fenja Steinert, Sebastian Lunemann, Christian Körner, Renée R. C. E. Schreurs, Marcus Altfeld, Daniel Perez, Konrad Reinshagen, Madeleine J. Bunders   +8 more
doaj   +1 more source

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage

Cell Reports, 2015
Recent studies have demonstrated that natural killer (NK) cells are able to undergo clonal expansion and contraction and to generate self-renewing memory cells after infection with mouse cytomegalovirus (MCMV).
Yosuke Kamimura, Lewis L. Lanier
doaj   +1 more source

Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]

, 2015
Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Alici, Alnabhan, Aversa, Bachanova, Bachanova, Bachanova, Benjamin, Benson, Benyunes, Berg, Berg, Bertaina, Betters, Biassoni, Biassoni, Bonanno, Bonanno, Braud, Burns, Burshtyn, Burshtyn, Caligiuri, Caligiuri, Campbell, Campbell, Cany, Carlens, Cheng, Cheng, Cho, Chouaib, Chu, Colonna, Conlon, Cooley, Cooley, Cosman, Curti, Denman, Durrieu, D’Andrea, Edinger, Escudier, Farag, Fehniger, Frei, Frohn, Fry, Fujisaki, Fujisaki, Garg, Gleason, Gleason, Glienke, Gong, Grimm, Gumperz, Guven, Hercend, Hontscha, Imai, Imamura, Introna, Introna, Introna, Iyengar, Jiang, Jiang, Jiang, Karlhofer, Karre, Kim, Kim, Klingemann, Klingemann, Klingemann, Knorr, Knorr, Koehl, Koehl, Koehl, Koepsell, Lang, Lapteva, Lee, Li, Li, Lim, Lim, Linn, Lister, Litwin, Liu, Ljunggren, Llano, Lotze, Lu, Luhm, Lundqvist, Lundqvist, Lundqvist, Mackall, Maus, McKenna, Meehan, Meyer-Monard, Miller, Miller, Miller, Miller, Miller, Oevermann, Olcese, Olioso, Parkhurst, Pende, Pende, Peragine, Perussia, Phillips, Phillips, Phillips, Pittari, Pittari, Rabinowich, Rettinger, Rizzieri, Romagne, Rosenberg, Rosenberg, Rosenberg, Rubnitz, Ruggeri, Rutella, Rutella, Rutella, Rutella, Schmeel, Schmidt-Wolf, Schmidt-Wolf, Schumm, Shah, Shaim, Shi, Shimasaki, Siegler, Soiffer, Somanchi, Somanchi, Spanholtz, Stern, Stroncek, Sutlu, Sweeney, Tam, Tam, Tam, Tanaka, Tomchuck, Tonn, Venstrom, Venstrom, Verneris, Vey, Vitale, Wagtmann, Wagtmann, Wiernik, Winter, Yan, Yang, Yoon, Yron, Zhang, Zhang   +174 more
core   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source