Results 41 to 50 of about 226,818 (311)

Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. [PDF]

, 1996
Natural killer (NK) cells and some T cells are endowed with receptors specific for class I major histocompatibility complex (MHC) molecules that can inhibit cellular effector functions.
Cado, D, Held, W, RAULET, David H.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]

, 1994
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson, Anderson, Bernot, Bucy, Bucy, Chan, Char, Chen, Chen, Chen, Chen, Chomczynski, Ciccone, Cihak, Coltey, Cooper, Dennert, Guillemot, Göbel, Hori, Hála, Laemmli, Lahti, Lanier, Lanier, Lillehoj, Mingari, Moretta, Myers, Nowak, Ortaldo, Phillips, Phillips, Poggi, Ratcliffe, Ritz, Rodewald, Schauenstein, Schnetzler, Sharma, Sowder, Spurr, Suzuki, Terry, Tjoelker, Trinchieri, Voss, Vujanovic, Wilson   +48 more
core   +1 more source

CD56^bright natural killer (NK) cells: an important NK cell subset

Immunology, 2009
SummaryHuman natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56bright CD16dim/− and CD56dim CD16+, respectively. In this review, we will focus on the CD56bright NK cell subset.
Aurélie, Poli, Tatiana, Michel, Maud, Thérésine, Emmanuel, Andrès, François, Hentges, Jacques, Zimmer   +5 more
openaire   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Immunomodulation of NK Cells by Ionizing Radiation

Frontiers in Oncology, 2020
Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive.
Jiarui Chen, Xingyu Liu, Zihang Zeng, Jiali Li, Yuan Luo, Wenjie Sun, Yan Gong, Yan Gong, Junhong Zhang, Junhong Zhang, Junhong Zhang, Qiuji Wu, Qiuji Wu, Qiuji Wu, Conghua Xie, Conghua Xie, Conghua Xie   +16 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A

Frontiers in Immunology, 2018
Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile.
Niken M. Mahaweni, Niken M. Mahaweni, Niken M. Mahaweni, Femke A. I. Ehlers, Femke A. I. Ehlers, Femke A. I. Ehlers, Gerard M. J. Bos, Gerard M. J. Bos, Lotte Wieten, Lotte Wieten   +9 more
doaj   +1 more source

Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapy

Frontiers in Immunology, 2023
Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in immunity by killing virally infected or tumor cells and secreting cytokines and chemokines.
Minchuan Zhang, Kong-Peng Lam, Kong-Peng Lam, Kong-Peng Lam, Shengli Xu, Shengli Xu   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source