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The need for natural killer T cells
Nature Medicine, 2005Natural killer T cells share properties of both T cells and natural killer cells. Absence of this unusual cell type might underlie the immune disorder X-linked lymphoproliferative disease ( pages 340–345 ).
MacDonald, H.R., Schümann, J.
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Natural killer T cells and haemopoiesis
British Journal of Haematology, 2006SummaryInvariant natural killer T (iNKT) cells are a small but powerful subset of regulatory T cells involved in the modulation of a variety of normal and pathological immune responses. In contrast to conventional or other types of regulatory T cells, they are activated by glycolipid and phospholipid ligands that are presented to them by the non ...
Anastasios, Karadimitris +2 more
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Natural killer T cells in atherosclerosis
Nature Reviews Cardiology, 2017Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT) cells in response to microbial pathogens and inflammatory disorders such as atherosclerosis has received ...
Godfrey S, Getz, Catherine A, Reardon
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Natural killer cells and natural killer T cells
Arthritis & Rheumatism, 2000NK cells are important in protecting against viral infections, and they may regulate the immune response. They are activated by hematopoietic blasts and pose a barrier to bone marrow transplantation. They are also abundant in the pregnant uterine decidua, although their role there is unknown.
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Natural Killer T Cells and Autoimmune Disease
Current Molecular Medicine, 2009Natural killer T (NKT) cells are an unusual subset of innate immune cells that express a surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the adaptive immune system. NKT cells express a highly restricted repertoire of T cell receptors that recognize glycolipid antigens bound with the antigen-presenting molecule CD1d.
Lan, Wu, Luc, Van Kaer
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Natural killer T cells and ulcerative colitis
Cellular Immunology, 2019Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease (IBD). Both innate immunity and adaptive immunity are aberrant in IBD. The pathogenesis of UC includes abnormal inflammation and immune responses of the digestive tract.
Li Jie, Lai, Jun, Shen, Zhi Hua, Ran
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Natural Killer T Cells and Asthma
New England Journal of Medicine, 2006Invariant natural killer T cells, originally characterized in mice and more recently defined in humans, are a unique, conserved T-cell sublineage possessing a rearrangement of the T-cell antigen receptor (Vα14Jα18 in mice and Vα24Jα18 in humans). Human natural killer T cells also have an invariant β chain (Vβ11). Vα24Vβ11 binds to glycolipids presented
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Cutaneous natural killer/T-cell lymphoma
Journal of the American Academy of Dermatology, 2002Lymphomas are classified as either Hodgkin's or non-Hodgkin's. The 2 subtypes of non-Hodgkin's lymphoma that can present primarily in the skin are cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, both of which tend to be low-grade malignant neoplasms.
Michael A, Radonich +2 more
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Immunotherapy with ligands of natural killer T cells
Trends in Molecular Medicine, 2002Natural killer T (NKT) cells are innate lymphocytes that share receptor structures and functions with conventional T cells and natural killer cells. NKT cells are specific for glycolipid antigens bound by the major histocompatibility complex class I-like protein CD1d. One striking property of NKT cells is their capacity to rapidly produce large amounts
Michael T, Wilson +2 more
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Extranodal Natural Killer T-Cell Lymphoma
New England Journal of Medicine, 2020Extranodal Natural Killer T-Cell Lymphoma A 53-year-old man presented with fever, dyspnea, and rapidly progressive skin lesions.
Kuan-Yu, Chi, Hsiu-Nien, Shen
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