Results 181 to 190 of about 6,334 (213)
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DETECTION OF MICROBES BY NATURAL KILLER T CELLS
2008Natural killer T (NKT) cells combine features of the innate and adaptive immune systems. For example, they are lymphocytes that express an αβ T cell antigen receptor (TCR), typical of adaptive immunity, but they also express NK receptors, such as NK1.1 (NKR-P1 or CD161c), similar to NK cells, which are part of the innate immune system.
Yuki, Kinjo, Mitchell, Kronenberg
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Imaging natural killer T cells in action
Immunology & Cell Biology, 2013Natural killer T (NKT) cells were first recognized more than two decades ago as a distinct lymphocyte lineage that regulates a broad range of immune responses. The activation of NKT cells paradoxically can lead to either suppression or stimulation of immune responses, but despite this uncertainty, many investigators are hopeful that immune therapies ...
Connie H Y, Wong, Paul, Kubes
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A role for natural killer T cells in asthma
Nature Reviews Immunology, 2006In several mouse models, natural killer T cells have recently been found to be required for the development of airway hyper-reactivity, a cardinal feature of asthma. Moreover, in patients with chronic asthma, natural killer T cells with a T-helper-2-like phenotype (that is, that express CD4 and produce T helper 2 cytokines) are present in the lungs in ...
Dale T, Umetsu, Rosemarie H, DeKruyff
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To be or not to be NKT: Natural killer T cells in the liver
Hepatology, 2004Much of the hepatology literature to date has focused on the adaptive, antigen-specific response mediated by classical T-cell populations in both the protection and pathogenesis of liver disease. However, the liver is selectively enriched for cells representative of innate immunity, including natural killer T (NKT) cells.
Exley, Mark A., Koziel, Margaret James
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Natural Killer T Cells in Mucosal Homeostasis
Annals of the New York Academy of Sciences, 2004Abstract: The mucosal‐associated lymphoid tissues (MALT), including the gut‐associated lymphoid tissues, are a tightly regulated environment. In fact, it might be stated that on the basis of studies from animal models of inflammatory bowel disease (IBD), the major means of peripheral regulation of immune responses in the intestine is not necessarily ...
Arthur, Kaser +6 more
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Testicular natural killer T‐cell lymphoma
International Journal of Urology, 2005Abstract Primary testicular lymphomas account for less than 5% of all testicular neoplasms. Testicular natural killer (NK)/T‐cell lymphomas are exceptional and have a very poor prognosis. We report the case of a 30‐year‐old French Caucasian man with testicular NK/T‐cell lymphoma of the following immunophenotype: CD2+, CD3ɛ+ and CD56+.
Charles, Ballereau +6 more
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Natural Killer T-Cell Lymphoma of the Tongue
Annals of Otology, Rhinology & Laryngology, 2005Lymphoma, which represents about 5.4% of all neoplasms and, more significantly, 19% to 28% of malignant neoplasms, is the most common nonepithelial malignancy of the head and neck area in Koreans. Natural killer T-cell (NK/T-cell) lymphoma is a lymphoma of putative natural killer cell lineage.
Kwang-Jae, Cho +2 more
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Activation of Natural Killer T Cells by Glycolipids
2006Natural killer T (NKT) cells are a distinct T-cell sublineage, originally named because of their coexpression of an alphabeta T cell antigen receptor (TCR) characteristic of T lymphocytes, and NK1.1, a C-type lectin expressed by natural killer (NK) cells. NKT cells use their TCR to recognize glycolipids bound to or presented by CD1d.
Emmanuel, Tupin, Mitchell, Kronenberg
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Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma
Cancer Cell, 2020Depei Wu, Rong Tao, Xi Zhang
exaly