Results 91 to 100 of about 3,616 (145)

TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.

PLoS ONE, 2012
K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner.
Alice C Newman, Caroline L Scholefield, Alain J Kemp, Michelle Newman, Edward G McIver, Ahmad Kamal, Simon Wilkinson   +6 more
doaj   +1 more source

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

mBio, 2020
The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-γ) is the major cytokine involved in
Jaya Bhushan, Joshua B. Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J. Lenschow, Herbert W. Virgin, L. David Sibley   +6 more
doaj   +1 more source

NDP52 and OPTN S177D S473D: expression and purification v1

, 2022
This protocol describes how to express and purify human NDP52 and OPTN S177D S473D. The same procedure can be applied to purify wild type OPTN.
openaire   +1 more source

NDP52, autophagie et pathogènes [PDF]

médecine/sciences, 2015
Pauline Verlhac, Christophe Viret, Mathias Faure   +2 more
openaire   +1 more source

TRIM26 facilitates PRV infection through NDP52-mediated MAVS autophagic degradation

, 2023
Abstract Pseudorabies virus (PRV) has evolved multiple strategies to evade host antiviral responses to benefit virus replication and establish persistent infection. Recently, tripartite motif 26 (TRIM26) belonging to TRIM family proteins is engaged in a broad range of biological processes involved in innate immunity, especially in regulating ...
Chengyue Wu, Mengdong Wang, Xiaoquan Wang, Yeping Chen, Hao Li, Liumei Sun, Jianle Ren, Zhendong Zhang   +7 more
openaire   +1 more source

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

eLife, 2016
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is ...
Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens   +10 more
doaj   +1 more source

Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses

Viruses, 2019
Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related Old-World mammarenaviruses. LASV causes severe hemorrhagic fever with high mortality in humans, whereas no case of MOPV infection has been reported.
Nicolas Baillet, Sophie Krieger, Alexandra Journeaux, Valérie Caro, Frédéric Tangy, Pierre-Olivier Vidalain, Sylvain Baize   +6 more
doaj   +1 more source

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Cell Reports
Summary: Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown.
Bhaskar Saha, Hallvard Olsvik, Geneva L. Williams, Seeun Oh, Gry Evjen, Eva Sjøttem, Michael A. Mandell   +6 more
doaj   +1 more source

Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

Nature Communications
The bacterial pathogen Neisseria gonorrhoeae is able to invade epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, the mechanistic details for interactions between gonococcal OMVs and ...
Shuai Gao, Lingyu Gao, Dailin Yuan, Xu’ai Lin, Stijn van der Veen   +4 more
doaj   +1 more source

NDP52, autophagy and pathogens: "The war then ceased for lack of combatants"

, 2015
International ...
Verlhac, Pauline, Viret, Christophe, Faure, Mathias   +2 more
openaire   +2 more sources