Results 71 to 80 of about 3,616 (145)

Selective Autophagy and Xenophagy in Infection and Disease

Frontiers in Cell and Developmental Biology, 2018
Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections.
Vartika Sharma, Surbhi Verma, Elena Seranova, Sovan Sarkar, Dhiraj Kumar   +4 more
doaj   +1 more source

Expression and purification protocol of GST-NDP52 v1

, 2021
This protocol details the expression and purification of GST-NDP52.
openaire   +1 more source

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, Volume 9, Issue 4, Page 652-673, April 2026.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

Cell Reports, 2023
Summary: The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a process that involves dynamic modulations of host organelles.
Mengyuan Zhao, Yong Zhang, Lihua Qiang, Zhe Lu, Zhuo Zhao, Yesheng Fu, Bo Wu, Qiyao Chai, Pupu Ge, Zehui Lei, Xinwen Zhang, Bingxi Li, Jing Wang, Lingqiang Zhang, Cui Hua Liu   +14 more
doaj   +1 more source

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, Volume 6, Issue 2, April 2026.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, Volume 16, Issue 3, Page 542-560, March 2026.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies [PDF]

Gastroenterology, 2013
Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional ...
Ellinghaus D., Zhang H., Zeissig S., Lipinski S., Till A., Jiang T., Stade B., Bromberg Y., Ellinghaus E., Keller A., Rivas M. A., Skieceviciene J., Doncheva N. T., Liu X., Liu Q., Jiang F., Forster M., Mayr G., Albrecht M., Hasler R., Boehm B. O., Goodall J., Berzuini C. R., Lee J., Andersen V., Vogel U., Kupcinskas L., Kayser M., Krawczak M., Nikolaus S., Weersma R. K., Ponsioen C. Y., Sans M., Wijmenga C., Strachan D. P., McArdle W. L., Vermeire S., Rutgeerts P., Sanderson J. D., Mathew C. G., Vatn M. H., Wang J., Nothen M. M., Duerr R. H., Buning C., Brand S., Glas J., Winkelmann J., Illig T., Latiano A., Annese V., Halfvarson J., D'Amato M., Daly M. J., Nothnagel M., Karlsen T. H., Subramani S., Rosenstiel P., Schreiber S., Parkes M., Franke A.   +60 more
openaire   +10 more sources