Results 51 to 60 of about 3,616 (145)
Purification of NDP52 (untagged) v1
, 2023 This protocol describes purification of NDP52 (untagged).
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INPP5D inhibits anti-malarial immunity by promoting IRF3 degradation through selective autophagy
Autophagy Reports, 2023 As a member of the inositol polyphosphate-5-phosphatase family, INPP5D (inositol polyphosphate-5-phosphatase D) is an important regulator of immune cell activation. To date, the mechanisms underlying anti-malarial immunity have not been elucidated.
Hongyu Li, Xiao Yu
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CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation [PDF]
Cell Death & Differentiation, 2018 Cell autonomous immunity is the ability of individual cells to initiate a first line of host defense against invading microbes, such as viruses. Autophagy receptors, a diverse family of multivalent proteins, play a key role in this host response by detecting, sequestering, and eliminating virus in a process termed virophagy.
Mohamud, Yasir +5 more
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Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy
Cell Death & Differentiation, 2021 The role of mitophagy, a process that allows the removal of damaged mitochondria from cells, remains unknown in multiple sclerosis (MS), a disease that is found associated with dysfunctional mitochondria. Here we have qualitatively and quantitatively studied the main players in PINK1-mediated mitophagy in peripheral blood mononuclear cells (PBMCs) of ...
Di Rita A1 +28 more
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Autophagy Reports, 2023 Mycobacterium tuberculosis (Mtb) promotes its intracellular persistence by subverting defense mechanisms, such as autophagy. Remarkably, enhancing autophagy is sufficient to trigger intracellular Mtb killing and effective immune response, making this ...
Alessandra Romagnoli +3 more
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p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways [PDF]
Journal of Biological Chemistry, 2011 Autophagy is an important mechanism of innate immune defense. We have recently shown that autophagy components are recruited with septins, a new and increasingly characterized cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin.
Mostowy, Serge +6 more
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mBio, 2023 Stringent control of the type I interferon (IFN-I) signaling is critical for host immune defense against infectious diseases, yet the molecular mechanisms that regulate this pathway remain elusive.
Hongyu Li +12 more
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TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy. [PDF]
J Biol ChemDamaged mitochondria are selectively eliminated in a process called mitophagy. PINK1 and Parkin amplify ubiquitin signals on damaged mitochondria, which are then recognized by autophagy adaptors to induce local autophagosome formation. NDP52 and OPTN, two essential mitophagy adaptors, facilitate de novo synthesis of pre-autophagosomal membranes near ...
Endo R +6 more
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Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy [PDF]
Molecular Cell, 2019 Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In this study, we used chemically inducible dimerization (CID) assays in tandem with CRISPR KO lines to systematically analyze ...
Vargas, JNS +7 more
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PLoS Pathogens, 2015 Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy receptors, including the myosin VI adaptor proteins optineurin and NDP52, have been shown to ...
David A Tumbarello +6 more
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