Results 31 to 40 of about 3,616 (145)

NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription [PDF]

Nature Communications, 2017
Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear ...
Natalia Fili, Yukti Hari-Gupta, Ália dos Santos, Alexander Cook, Simon Poland, Simon M. Ameer-Beg, Maddy Parsons, Christopher P. Toseland   +7 more
doaj   +9 more sources

TRIM26 facilitates PRV infection through NDP52-mediated autophagic degradation of MAVS

Veterinary Research
Pseudorabies virus (PRV) has evolved multiple strategies to evade host antiviral responses to benefit virus replication and establish persistent infection.
Wu Chengyue, Wang Mengdong, Wang Xiaoquan, Chen Yeping, Li Hao, Sun Liumei, Ren Jianle, Zhang Zhendong   +7 more
doaj   +3 more sources

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens. [PDF]

Cell Rep
Summary: Host cell cytosol is monitored by inflammasomes. Cytosolic invasion of pathogens involves breaching endolysosomal membranes, which is sensed by galectins triggering endolysosomal damage response.
Shivcharan S, Younis DA, Wright SS, Wang C, Behl B, Shumba P, Delgado KN, Chawla AK, Alto NM, Panjwani N, Vanaja SK, Ruan J, Fan Z, Rathinam VA.   +13 more
europepmc   +2 more sources

Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption. [PDF]

Adv Sci (Weinh)
Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms of aloe emodin in the protection of radiation‐induced heart damage (RIHD) are unclear.
Ouyang F, Li Y, Wang H, Liu X, Tan X, Xie G, Zeng J, Zeng G, Luo Q, Zhou H, Chen S, Hou K, Fang J, Zhang X, Zhou L, Li Y, Gao A.   +16 more
europepmc   +2 more sources

Corrigendum: Dual NDP52 Function in Persistent CSFV Infection [PDF]

Frontiers in Microbiology, 2021
Shuangqi Fan, Keke Wu, Chaowei Luo, Xin Li, Mengpo Zhao, Dan Song, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jun Li, Mingqiu Zhao, Jinding Chen   +13 more
doaj   +2 more sources

UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment. [PDF]

Int J Mol Sci
Mitophagy, as a critical form of selective autophagy, plays a central role in maintaining cellular homeostasis. While the canonical PTEN-Induced Kinase 1 (PINK1)–Parkin pathway is well established, mitophagy can still be effectively induced in Parkin-deficient cells such as HeLa, indicating the existence of Parkin-independent alternative pathways.
Jin B, Qu J, Xu K, Zhang Y, Xu P, Wang X, Zhao B, Jiao X.   +7 more
europepmc   +4 more sources

Rapid activation of p62 body-mediated autophagy in human cells under hyperosmotic stress. [PDF]

Commun Biol
The autophagy receptor p62 is degraded via autophagy under hyperosmotic stress, but whether this involves the formation of biomolecular condensates (p62 bodies) remains unclear.
Tamura N, Waguri S.
europepmc   +2 more sources

The Neglected Role of GSDMD C-Terminal in Counteracting Type I Interferon Signaling. [PDF]

Adv Sci (Weinh)
The GSDMD N‐terminal fragment (GSDMD‐NT)‐mediated pyroptosis is extensively investigated. However, the role of the C‐terminal domain of GSDMD (GSDMD‐CT) is unexplored. This study demonstrates that GSDMD‐CT acts as a negative regulator that suppresses IFN‐
Xu W, He S, Shi W, Xu J, Liu S, Yu Z, Li D, Jin Q, Wang Y, Zhang Z, Lv Q, Ge Y, Li Y, Li X, Chen N, Fu X, Yang Y, Shi F.   +17 more
europepmc   +2 more sources

Role of Pink1-mediated mitophagy in adenomyosis [PDF]

PeerJ, 2023
Background Recent studies indicate that endometrial hypoxia plays a critical role in adenomyosis (AM) development. Mitochondria are extremely sensitive to hypoxic damage, which can result in both morphological and functional impairment.
Minmin Chen, Wei Wang, Xianyun Fu, Yongli Yi, Kun Wang, Meiling Wang   +5 more
doaj   +2 more sources

Dual function of CALCOCO2/NDP52 during xenophagy [PDF]

Autophagy, 2015
During xenophagy, pathogens are selectively targeted by autophagy receptors to the autophagy machinery for their subsequent degradation. In infected cells, the autophagy receptor CALCOCO2/NDP52 targets Salmonella Typhimurium to the phagophore membrane by concomitantly interacting with LC3C and binding to ubiquitinated cytosolic bacteria or to LGALS8 ...
Verlhac, Pauline, Viret, Christophe, Faure, Mathias   +2 more
openaire   +4 more sources