Results 41 to 50 of about 3,616 (145)
NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
The EMBO Journal, 2022 Abstract Mitophagy, the elimination of mitochondria via the autophagy‐lysosome pathway, is essential for the maintenance of cellular homeostasis. The best characterised mitophagy pathway is mediated by stabilisation of the protein kinase PINK1 and recruitment of the ubiquitin ligase Parkin to damaged mitochondria.
Tetsushi Kataura +15 more
openaire +4 more sources
Cell Death and Disease, 2021 Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3
Cheng Zhang +11 more
doaj +1 more source
Frontiers in Microbiology, 2021 Enteroviruses (EVs) usurp the host autophagy pathway for pro-viral functions; however, the consequence of EV-induced diversion of autophagy on organelle quality control is poorly defined.
Yasir Mohamud +11 more
doaj +1 more source
Expression and purification of mCherry-NDP52 v1
, 2022 This protocol describes how to express in E.Coli human NDP52 N-terminally tagged with mCherry and purify it through His affinity purification followed by Size Exclusion Chromatography.
Daniel Bernklau +2 more
openaire +2 more sources
eLife, 2020 The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 ...
Xiaoshan Shi +4 more
doaj +1 more source
PLoS Pathogens, 2023 Kaposi's sarcoma-associated herpesvirus (KSHV) causes the inflammatory and angiogenic endothelial cell neoplasm, Kaposi's sarcoma (KS). We previously demonstrated that the KSHV Kaposin B (KapB) protein promotes inflammation via the disassembly of ...
Carolyn-Ann Robinson +6 more
doaj +1 more source
Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation
Scientific Reports, 2021 Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages.
Yuta Kono +10 more
doaj +1 more source
NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria [PDF]
Autophagy, 2010 Autophagy functions as a cell-autonomous effector mechanism of innate immunity by separating bacteria from cytosolic resources and delivering them for lysosomal destruction. How cytosolic bacteria are targeted for autophagy is incompletely understood.
Natalia, von Muhlinen +4 more
openaire +2 more sources
NDP52: the missing link between ubiquitinated bacteria and autophagy [PDF]
Nature Immunology, 2009 Mammalian cells ubiquitinate bacteria that erroneously enter the cytosol and target these intruding microbes for destruction by autophagy. New work shows that the protein NDP52 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds these invaders.
Stanimir Ivanov, Craig R Roy
openaire +1 more source
Cell Death and Disease, 2023 Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to promote transcription by interacting with several transcription factors in the DNA–binding complexes.
Ning Mu +9 more
doaj +1 more source