Results 21 to 30 of about 3,616 (145)

Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: <i>in vivo</i> and <i>in vitro</i> studies. [PDF]

Front Pharmacol
BackgroundSlow-transit constipation (STC) is a widespread functional gastrointestinal condition distinguished by decreased colonic motility as an essential clinical characteristic.
Wang Y, Wang X, Qian Y, Sun M, Yang H, Su L, Yan S.   +6 more
europepmc   +2 more sources

PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation. [PDF]

J Virol
Porcine epidemic diarrhea virus (PEDV) leads to a high mortality in neonatal piglets and causes serious harm to the global swine industry. PEDV has been shown to exploit diverse strategies for antagonism of host innate immunity and promotion of self ...
Yang L, Qian Q, Sun Y-g, Chen X-x, Xing G, Zhang J-q, Xing B-s, Qiao S, Li R, Zhang G.   +9 more
europepmc   +2 more sources

Aβ1‐42‐induced Mitochondrial Dysfunction in Human Neuroblastoma M17 cells: Time‐dependent Impact on Mitochondria [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that affects geriatric populations across the globe. Deposition of the Aβ peptide in the brain is considered a central event of AD pathology. Mitochondrial dysfunction is a characteristic feature of AD.
Jayatunga D, Hone E, Martins R.
europepmc   +2 more sources

Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2. [PDF]

Nat Commun
The clinical outcome of SARS-CoV-2 infection spans from asymptomatic viral elimination to lethal COVID-19 pneumonia, which is due to type I interferon (IFN) deficiency in at least 15–20% of cases. We report two unrelated male patients with critical COVID-
Hu L, van der Sluis RM, Castelino KB, Zhang BC, Ronit A, Zillinger T, Werner M, Jørgensen SE, Hansen AL, Pedersen A, Narita R, Reinert LS, Bundgaard B, COVID Human Genetic Effort, Holm CK, Cobat A, Casanova JL, Reggiori F, Mari M, Paludan SR, Mogensen TH.   +20 more
europepmc   +2 more sources

FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein. [PDF]

Front Immunol
Porcine deltacoronavirus (PDCoV), a newly discovered intestinal coronavirus, has rapidly spread among pigs worldwide and has shown the potential for cross-species infection.
Ji L, Zhou L, Wang Y, Yang S, Liu Y, Wang X, Shen Q, Zhou C, Xu J, Zhang W.   +9 more
europepmc   +2 more sources

Correction to "From Mitochondria to Immunity: The Emerging Roles of Mitochondria-Derived Vesicles and Small Extracellular Vesicles in Cellular Communication and Disease". [PDF]

J Extracell Vesicles
Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
europepmc   +2 more sources

PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy. [PDF]

Vet Sci
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel enteric coronavirus that causes severe clinical diarrhea and intestinal pathological injury in pigs.
Zhao C, Qin Y, Huang H, Chen W, Hu Y, Zhang X, Li Y, Lan T, Sun W.   +8 more
europepmc   +2 more sources

A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer's disease. [PDF]

Cell Death Dis
Selective elimination of early pathological TAU species may be a promising therapeutic strategy to reduce the accumulation of TAU, which contributes to neurodegeneration and is a hallmark of Alzheimer’s disease (AD). Pathological hyper-phosphorylated TAU
Mattioni A, Carsetti C, Bruqi K, Caputo V, Cianfanelli V, Bacalini MG, Casa M, Gabelli C, Giardina E, Cestra G, Strappazzon F.   +10 more
europepmc   +2 more sources

The Interaction Between Mitophagy Dysregulation and the Diabetic Bladder Microenvironment [PDF]

J Diabetes
Hyperglycemia suppresses the PINK1/Parkin pathway, impairing mitophagy and triggering ROS accumulation. This activates NLRP3 inflammasome and AGEs‐RAGE axis, driving bladder inflammation and fibrosis. A bidirectional positive feedback loop forms between mitophagy dysregulation and microenvironment deterioration, accelerating diabetic bladder ...
Li S, Fan Z, Duan Z, Xue J, Wei Z.
europepmc   +2 more sources

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy [PDF]

Nature Communications, 2019
Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional ...
Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K. Nguyen, Michael Lazarou   +5 more
doaj   +3 more sources