Dual NDP52 Function in Persistent CSFV Infection [PDF]
Frontiers in Microbiology, 2020 Viruses have evolved many mechanisms to escape host antiviral responses. Previously, we found that classical swine fever virus (CSFV) infection induces autophagy using the autophagosome as a self-replication site, thereby evading the host immune response
Mingqiu Zhao +2 more
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NDP52 deficiency accelerates chondrocyte degeneration through promoting pathogenic mitochondrial ROS via reverse electron transport [PDF]
Redox BiologyNDP52, a constituent of the selective autophagy receptors (SARs), was recognized for its involvement in facilitating substrate degradation via autophagic bridging. However, its autonomous function apart from autophagy remained largely unexplored.
Jiechao Xia
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NDP52 and its emerging role in pathogenesis. [PDF]
Cell Death DisAutophagy is a pro-survival process that regulates the degradation and renewal of cellular components, making it a crucial mechanism for cellular homeostasis.
Bruqi K, Strappazzon F.
europepmc +4 more sources
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy [PDF]
Frontiers in Immunology, 2021 Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate ...
Daisuke Oikawa +2 more
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Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription
Nature Communications, 2023 NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nuclear functions
Alia Dos Santos +2 more
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Nature Communications, 2023 Autophagy receptor NDP52 triggers bacterial autophagy against infection. However, the ability of NDP52 to protect against viral infection has not been established.
Jianjin Zhao +2 more
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Handcuffs for bacteria - NDP52 orchestrates xenophagy of intracellular Salmonella [PDF]
Microbial Cell, 2015 Eukaryotic cells can selectively target and degrade intracellular pathogens using autophagy, a process referred to as xenophagy. This selectivity is controlled by proteins called autophagy receptors, which can recognise pathogens and address ...
Pauline Verlhac +2 more
doaj +4 more sources
E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8. [PDF]
J VirolPorcine epidemic diarrhea virus (PEDV), a highly lethal alpha coronavirus, primarily infects piglet intestines, yet the role of the intestinal homeostasis regulator NEDD4—a HECT-family E3 ubiquitin ligase—in PEDV infection was previously unknown.
Guo X +15 more
europepmc +2 more sources
Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN
Cells, 2022 The elimination of intracellular components by autophagy maintains metabolic homeostasis and is a quality-control pathway that enables organelle regeneration.
Po-Yuan Ke +2 more
doaj +7 more sources
BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway. [PDF]
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry.
Zhao C +11 more
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