Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents [PDF]
, 2019 A series of cationic chlorido arene-iridium(III) and arene-osmium(II) complexes with bidentate pyridyl functionalized mesoionic carbenes (MIC) of the 1,2,3-triazol-5-ylidene type have been prepared.
Bolje, Aljoša +12 more
core +1 more source
RIPK1 protects from TNF-α-mediated liver damage during hepatitis [PDF]
, 2016 Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function.
Bertin, John +11 more
core +1 more source
Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
Nature CommunicationsReceptor-interacting protein kinase 3 (RIPK3), a key regulator of necroptosis, is modulated by ubiquitination through various E3 ligases and deubiquitinases.
Chi Hyun Hwang +9 more
doaj +1 more source
Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes.
PLoS ONE, 2014 Human immunodeficiency virus type 1 (HIV-1) infection is characterized by progressive depletion of CD4+ T lymphocytes and dysfunction of the immune system.
Ting Pan +11 more
doaj +1 more source
Regulation of cell death in cancer - possible implications for immunotherapy [PDF]
, 2013 Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape.
Fulda, Simone
core +2 more sources
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]
, 2019 TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn +10 more
core +1 more source
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]
, 2016 Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson +27 more
core +1 more source
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]
, 2019 The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis +17 more
core +6 more sources
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]
, 2019 PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher +9 more
core +3 more sources
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source