Results 1 to 10 of about 60,497 (319)
The double-edged functions of necroptosis
Cell Death and Disease, 2023 Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that
Keng Ye, Zhimin Chen, Yanfang Xu
doaj +2 more sources
The role of necroptosis in cancer biology and therapy
Molecular Cancer, 2019 Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong +10 more
doaj +2 more sources
CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN [PDF]
Cell Reports, 2016 Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are ...
Diana Legarda +11 more
doaj +3 more sources
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cellular & Molecular Immunology, 2021 Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity.
D. Bertheloot, E. Latz, B. S. Franklin
semanticscholar +1 more source
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Signal Transduction and Targeted Therapy, 2022 In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to ICIs, partly caused by the absence of tumor ...
Weitong Gao +4 more
semanticscholar +1 more source
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
doaj +1 more source
Journal of Hematology & Oncology, 2022 Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of ...
Xuhui Tong +8 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis ...
Rui Zu +14 more
doaj +1 more source
Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19
European Journal of Medical Research, 2022 The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant threat to global health. There are currently no drugs available for effective treatment. Severe cases of
Yongan Kang, Qinghai Wang
doaj +1 more source
Frontiers in Genetics, 2022 The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression of 26
Qiwei Wang +3 more
doaj +1 more source