Results 11 to 20 of about 51,913 (289)
CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN [PDF]
Cell Reports, 2016 Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are ...
Diana Legarda +11 more
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Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators [PDF]
Experimental & Molecular Medicine, 2021 AbstractNecroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme ...
Jinho Seo +4 more
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Cell Death and Disease, 2021 Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis ...
Rui Zu +14 more
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p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
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Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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The double-edged functions of necroptosis
Cell Death and Disease, 2023 Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that
Keng Ye, Zhimin Chen, Yanfang Xu
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Necroptosis in Cholangiocarcinoma [PDF]
Cells, 2020 Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and is regulated by receptor-interacting protein kinases 1 and 3 and mixed-lineage kinase domain-like ...
Sarcognato, S +4 more
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Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19
European Journal of Medical Research, 2022 The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant threat to global health. There are currently no drugs available for effective treatment. Severe cases of
Yongan Kang, Qinghai Wang
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Frontiers in Genetics, 2022 The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression of 26
Qiwei Wang +3 more
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JAK-STAT, 2012 TNF-induced necroptosis is caused by the activation of RIPK1 and the subsequent production of reactive oxygen species in the mitochondria, although the intermittent molecules of the signaling pathway responsible for this ROS-mediated type of programmed necrosis have not yet been identified.
Georgiadis, Vassilis, Knight, Richard A.
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