Results 11 to 20 of about 60,497 (319)
Necroptosis and tumor progression.
Trends in Cancer, 2021 Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases.
Jiong Yan +3 more
semanticscholar +3 more sources
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators [PDF]
Experimental & Molecular Medicine, 2021 AbstractNecroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme ...
Jinho Seo +4 more
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Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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Necroptosis in Cholangiocarcinoma [PDF]
Cells, 2020 Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and is regulated by receptor-interacting protein kinases 1 and 3 and mixed-lineage kinase domain-like ...
Sarcognato, S +4 more
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Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Cell, 2022 Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined.
C. Weindel +16 more
semanticscholar +1 more source
JAK-STAT, 2012 TNF-induced necroptosis is caused by the activation of RIPK1 and the subsequent production of reactive oxygen species in the mitochondria, although the intermittent molecules of the signaling pathway responsible for this ROS-mediated type of programmed necrosis have not yet been identified.
Georgiadis, Vassilis, Knight, Richard A.
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Frontiers in Genetics, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Yibo Ma +5 more
doaj +1 more source
Necroptosis in viral infections: a twilight among progeny dissemination and host defense [PDF]
Infectious Diseases and Tropical Medicine, 2023 Decades ago, a unique cell death pathway was reported, namely ‘Necroptosis’, that exhibits both the characteristics of apoptosis, the programmed cell death mechanism, as well as the unprogrammed necrotic cell death pathway.
S. Ghosh
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Targeting necroptosis in anticancer therapy: mechanisms and modulators
Acta Pharmaceutica Sinica B, 2020 Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance.
Ying Wu, Guoqiang Dong, Chunquan Sheng
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RIPK3: Beyond Necroptosis [PDF]
Immunity, 2019 In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
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