Results 251 to 260 of about 60,497 (319)

Irigenin Modulates BL‐Induced Pyroptosis in Retinal Pigment Epithelial Cells Through p38 MAPK and NFκB Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 2, February 2026.
Irigenin alleviates blue light‐induced RPE cell damage by inhibiting NLRP3 inflammasome and p38/NF‐κB signalling, showing potential for AMD prevention. ABSTRACT Age‐related macular degeneration (AMD), a primary cause of vision loss among older adults, is strongly associated with inflammatory processes.
I‐Li Su, Kun‐Lin Yeh, Chien‐Ying Lee, Sheng‐Chien Lin, Chen‐Yu Chiang, Chun‐Jung Chen, Wen‐Ying Chen, Ching‐Chi Tseng, Yin‐Che Lu, Yu‐Hsiang Kuan   +9 more
wiley   +1 more source

Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission. [PDF]

J Am Heart Assoc
Shimada K, Yamaguchi I, Miyamoto T, Korai M, Koyama H, Enomoto N, Shimabuku A, Kitazato KT, Kanematsu Y, Takagi Y.   +9 more
europepmc   +1 more source

Enhanced Expression of IL32 mRNA in Skeletal Muscles in the Context of Head and Neck Carcinomas

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cancer‐related sarcopenia (CRS) is a significant complication of head and neck carcinoma (HNC), characterised by muscle degeneration and poor clinical outcomes. Although various dietary and therapeutic interventions have been explored, most of them remain empirical, and the molecular mechanisms underlying CRS are not yet fully ...
Imane Baïche, Héla Hachicha, Thierry Ragot, Céline Gracia, Aurore Gelin, Anaïs Gader, Caroline Even, Ingrid Breuskin, Odile Casiraghi, Thibault Dayris, Filippo Dall'Ollio, Catherine Brenner, Karim Benihoud, Yegor Vassetzky, François Bidault, Philippe Gorphe, Pierre Busson, Fei Chen   +17 more
wiley   +1 more source

PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells. [PDF]

iScience
Zhu Z, Liang Y, Liu X, Kong F, Sun K, Xu X, Shi J.   +6 more
europepmc   +1 more source

Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology

MedComm, Volume 7, Issue 2, February 2026.
Traditional Chinese medicine (TCM) faces great challenges during the development of modern medicine. Utilizing novel technologies such as artificial intelligence (AI) and nanotechnology facilitates TCM with great potential in precision diagnosis and improved treatments efficacy.
Wenqi Yu, Mengzhen Chen, Xueqi Tan, Xi Wei, Fan Sun, Hua Yan, Xue Xu, Hongcai Shang   +7 more
wiley   +1 more source

Resident alveolar macrophages are highly susceptible to the induction of RIPK1/RIPK3-mediated necroptosis which promote efficient pulmonary immune response. [PDF]

Cell Death Dis
Adachi T, Matsushita K, Yasuda K, Nakahira M, Imasaka M, Sugimoto M, Yang Z, Kobiyama K, Hayashi T, Ishii KJ, Yoshioka Y, Ohmuraya M, Shirasaki Y, Kuroda E.   +13 more
europepmc   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Cracking the code of cancer immunotherapy resistance: emerging roles of pyroptosis and necroptosis. [PDF]

J Exp Clin Cancer Res
Lei K, Chen J, Deng Y, Peng Y, Zhai X, Ren X, Zhao J, Chen B, Jiang C.   +8 more
europepmc   +1 more source

Integrated Multi‐Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic Colitis

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi, Ana Maria Gonzalez‐Castro, Yamile Zabana, Fernando Fernández‐Bañares, Andreas Münch, Eva Tristan, Juan‐José Lozano, Julia Sidorova, Beatriz Lobo, Carmen Alonso‐Cotoner, Elba Exposito, Alfredo J. Lucendo, Stefania Landolfi, Ana Benages, Ronald Llerena‐Castro, Maria Dolores Castillo Cejas, Joan Dot, Javier Santos, Maria Vicario   +18 more
wiley   +1 more source

Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro. [PDF]

Front Immunol
Luo D, Liu J, Ya L, Ruan C, Ou S, Wei Y, Lin Q, Huang Z, Nong K.   +8 more
europepmc   +1 more source