Results 21 to 30 of about 51,913 (289)
Frontiers in Genetics, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Yibo Ma +5 more
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Targeting necroptosis in anticancer therapy: mechanisms and modulators
Acta Pharmaceutica Sinica B, 2020 Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance.
Ying Wu, Guoqiang Dong, Chunquan Sheng
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Integrated stress response restricts macrophage necroptosis
Life Science Alliance, 2022 Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place +3 more
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Necroptosis in viral infections: a twilight among progeny dissemination and host defense [PDF]
Infectious Diseases and Tropical Medicine, 2023 Decades ago, a unique cell death pathway was reported, namely ‘Necroptosis’, that exhibits both the characteristics of apoptosis, the programmed cell death mechanism, as well as the unprogrammed necrotic cell death pathway.
S. Ghosh
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RIPK3: Beyond Necroptosis [PDF]
Immunity, 2019 In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
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Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]
, 2012 For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor +6 more
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Frontiers in Pharmacology, 2022 Background: Necroptosis is closely related to tumorigenesis and development. Accumulating evidence has revealed that long non-coding RNAs (lncRNAs) are also central players in osteosarcoma (OS).
Binfeng Liu +9 more
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Trends in Cancer, 2017 Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest.
Ayaz, Najafov +2 more
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Phenytoin inhibits necroptosis [PDF]
Cell Death & Disease, 2018 AbstractReceptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL) to cause plasma membrane rupture.
von Mässenhausen, Anne +27 more
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Targeting necroptosis in fibrosis
Molecular Biology Reports, 2023 AbstractNecroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases ...
Hassanein, Emad H. M. +5 more
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