Results 51 to 60 of about 51,913 (289)
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis
Communications Biology, 2023 Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL.
Fangmin Huang +12 more
doaj +1 more source
Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao +3 more
doaj +1 more source
Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
Cell Death and Disease, 2023 Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases.
Mayu Sun +10 more
doaj +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor
Frontiers in Cell and Developmental Biology, 2020 As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang +5 more
doaj +1 more source
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M +5 more
core +1 more source
ZBP1 mediates interferon-induced necroptosis [PDF]
Cellular & Molecular Immunology, 2019 Interferons (IFNs) play an important role in immunomodulatory and antiviral functions. IFN-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1 (RIPK1), Fas-associated protein with death domain (FADD), or caspase-8, but the mechanism is largely unknown. Here, we report that the DNA-dependent activator of IFN
Daowei, Yang +8 more
openaire +2 more sources
Methodology of drug screening and target identification for new necroptosis inhibitors
Journal of Pharmaceutical Analysis, 2019 Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported.
Pengchao Pan +4 more
doaj +1 more source