Results 51 to 60 of about 60,497 (319)

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Frontiers in Cell and Developmental Biology, 2020
As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang, Xixi Chang, Jinli Feng, Jiyun Yu, Jiyun Yu, Guozhu Chen   +5 more
doaj   +1 more source

Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist

Cell Death and Disease, 2023
Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases.
Mayu Sun, Xueqi Ma, Wei Mu, Haonan Li, Xiaoming Zhao, Tengfei Zhu, Jingquan Li, Yongliang Yang, Haibing Zhang, Qian Ba, Hui Wang   +10 more
doaj   +1 more source

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways

Computational and Structural Biotechnology Journal, 2021
Graphical ...
Yaqiu Wang, T. Kanneganti
semanticscholar   +1 more source

Methodology of drug screening and target identification for new necroptosis inhibitors

Journal of Pharmaceutical Analysis, 2019
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported.
Pengchao Pan, Zhenyu Cai, Chunlin Zhuang, Xiaofei Chen, Yifeng Chai   +4 more
doaj   +1 more source

Identification and Analysis of Necroptosis-Related Genes in COPD by Bioinformatics and Experimental Verification

Biomolecules, 2023
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex progressive inflammatory disease. Necroptosis is a newly identified type of programmed cell death. However, the role of necroptosis in COPD is unclear.
Yingxi Wang, Xin Su, Yan Yin, Qiuyue Wang   +3 more
doaj   +1 more source

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]

, 2018
Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev, A Degterev, A Kaczmarek, A Polykratis, B Shutinoski, C Fearns, CP Dillon, D Ofengeim, DE Christofferson, DM Monack, DM Moquin, DR Green, EW Harhaj, F Ginhoux, G Dougan, H Sakamoto, I Jaco, J Hitomi, JW Upton, K Newton, KE Lawlor, L Duprez, L Eckmann, L Galluzzi, LA O’Neill, M Belosevic, M Pasparakis, MA Brennan, MJ Bertrand, N Arpaia, N Bidere, N Festjens, N Robinson, N Shembade, N Takahashi, N Vanlangenakker, N. Peltzer, P Mandal, P Vandenabeele, P Vandenabeele, R Bellamy, R Patel, RE Voll, S Akira, S He, S He, S Malladi, S McComb, S McComb, S McComb, S McComb, SB Berger, SC Sun, SP Salcedo, ST Beug, T McQuade, T Vanden Berghe, T Xie, TH Chuang, W Declercq, W Reiley, WD Cook, WJ Kaiser, WW Reiley, XN Wu, Y Dondelinger, YS Cho, Z Cai   +67 more
core   +2 more sources

Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections

Cell Death and Disease, 2022
Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of the best-characterized regulated necrosis.
Guangzhi Zhang, Jinyong Wang, Zhanran Zhao, Ting Xin, Xuezheng Fan, Qingchun Shen, Abdul Raheem, Chae Rhim Lee, Hui Jiang, Jiabo Ding   +9 more
doaj   +1 more source

4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1

Frontiers in Cell and Developmental Biology, 2021
Background: Necroptosis is a vital regulator of myocardial ischemia/reperfusion (MI/R) injury. Meanwhile, 4-hydroxy-2-nonenal (4-HNE) is abundantly increased during MI/R injury. However, whether 4-HNE induces cardiomyocyte necroptosis during MI/R remains
Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Shukun Sun, Shukun Sun, Shukun Sun, Shukun Sun, Shukun Sun, Shukun Sun, Yu Han, Yu Han, Yu Han, Yu Han, Yu Han, Yu Han, Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Ruochuan Li, Ruochuan Li, Ruochuan Li, Ruochuan Li, Ruochuan Li, Ruochuan Li, Tonghui Xu, Tonghui Xu, Tonghui Xu, Tonghui Xu, Tonghui Xu, Tonghui Xu, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang, Shujian Wei, Shujian Wei, Shujian Wei, Shujian Wei, Shujian Wei, Shujian Wei, Yuguo Chen, Yuguo Chen, Yuguo Chen, Yuguo Chen, Yuguo Chen, Yuguo Chen   +72 more
doaj   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M, Guo, L, Moss, SE, Shi, H, Stampoulis, D, Williams, JA   +5 more
core   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources