Results 61 to 70 of about 60,497 (319)
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
Cell, 2020 Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase (MLKL)-dependent necroptosis in infected cells ...
Ting Zhang +19 more
semanticscholar +1 more source
ZBP1 mediates interferon-induced necroptosis [PDF]
Cellular & Molecular Immunology, 2019 Interferons (IFNs) play an important role in immunomodulatory and antiviral functions. IFN-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1 (RIPK1), Fas-associated protein with death domain (FADD), or caspase-8, but the mechanism is largely unknown. Here, we report that the DNA-dependent activator of IFN
Daowei, Yang +8 more
openaire +2 more sources
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]
, 2017 Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L. +26 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2020 Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death ...
Shelbi L. Christgen +5 more
semanticscholar +1 more source
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis [PDF]
The EMBO Journal, 2021 AbstractMixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption.
Zikou Liu +16 more
openaire +3 more sources
Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao +3 more
doaj +1 more source
Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. [PDF]
, 2016 The death receptor, Fas, triggers apoptotic death and is essential for maintaining homeostasis in the peripheral lymphoid organs. RIP1 was originally cloned when searching for Fas-binding proteins and was later shown to associate also with the signaling ...
Bertin, John +4 more
core +2 more sources
Necroptosis in development and diseases [PDF]
Genes & Development, 2018 Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions. Modulating the activation of RIPK1 by ubiquitination and phosphorylation is critical to control both ...
Shan, Bing +3 more
openaire +2 more sources
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. [PDF]
PLoS ONE, 2016 Necroptosis as a molecular program, rather than simply incidental cell death, was established by elucidating the roles of receptor interacting protein (RIP) kinases 1 and 3, along with their downstream partner, mixed lineage kinase-like domain protein ...
Wei Lu +7 more
doaj +1 more source