Results 71 to 80 of about 60,497 (319)

Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis [PDF]

, 2018
We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 ...
Anglani F., Ceol M, Cristofaro R, Del Prete D, Furlan C, Gianesello L, Priante G, Quaggio F, Terrin L   +8 more
core   +1 more source

Optineurin functions for optimal immunity [PDF]

, 2018
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core   +1 more source

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

Frontiers in Cellular and Infection Microbiology, 2020
Programmed cell death is regulated by evolutionarily conserved pathways that play critical roles in development and the immune response. A newly recognized pathway for proinflammatory programmed cell death called PANoptosis is controlled by a recently ...
Parimal Samir, R. Malireddi, T. Kanneganti   +2 more
semanticscholar   +1 more source

3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

Theranostics, 2023
Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric restriction (CR) and have been shown to have therapeutic effects in neuroinflammatory disease.
Haojie Zhang, W. Ni, Gaoxiang Yu, Yibo Geng, Junsheng Lou, J. Qi, Yituo Chen, Feida Li, Hantao Ye, Haiwei Ma, Hui Xu, Lu-Don Zhao, Yuepiao Cai, Xiangyang Wang, Huazi Xu, Jian Xiao, Kailiang Zhou   +16 more
semanticscholar   +1 more source

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

Immunological Reviews, 2020
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced during influenza virus infection induces cell death in the form of pyroptosis ...
Min Zheng, T. Kanneganti
semanticscholar   +1 more source

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
New research has shown that the development of osteoarthritis (OA) is regulated by different mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of action among various cytokines, cell death processes and OA is important
Jian Yang, Sha-sha Hu, Yangyang Bian, Jiangling Yao, Dong Wang, Xiaoqian Liu, Zhengdong Guo, Siyuan Zhang, Lei Peng   +8 more
semanticscholar   +1 more source

Necroptosis in Macrophage Foam Cells Promotes Fat Graft Fibrosis in Mice

Frontiers in Cell and Developmental Biology, 2021
Background: Fibrosis is a major grafting-related complication that leads to fat tissue dysfunction. Macrophage-induced inflammation is related to the development of fat tissue fibrosis.
Xihang Chen, Zilong Deng, Jingwei Feng, Qiang Chang, Feng Lu, Yi Yuan   +5 more
doaj   +1 more source

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation

Nature, 2020
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood 1 – 3 . Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zα domains that bind Z-
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer, Juan Lin, R. Eren, Amanda D. Fisher, Rebecca K. Lane, G. Young, G. Kassiotis, W. Kaiser, M. Pasparakis   +11 more
semanticscholar   +1 more source

Programmed necrosis and necroptosis signalling [PDF]

The FEBS Journal, 2014
In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling ...
Maria, Feoktistova, Martin, Leverkus
openaire   +2 more sources