Results 81 to 90 of about 60,497 (319)
Depletion of mitochondria in mammalian cells through enforced mitophagy [PDF]
, 2016 Mitochondria are not only the 'powerhouse' of the cell; they are also involved in a multitude of processes that include calcium storage, the cell cycle and cell death.
Correia-Melo, Clara +3 more
core +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources
Advancement of science, 2023 In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the younger population. Effective treatment is crucial for improving patients’ survival outcomes.
Xudong Zhu, Shenglong Li
semanticscholar +1 more source
Necroptosis DAMPens anti-tumor immunity [PDF]
Cell Death Discovery, 2016 Pancreatic ductal adenocarcinoma (PDA) causes a highly lethal cancer and is predicted to become the second most common cause of cancer-related death by 2030.1 In 2012, the number of deaths due to pancreatic cancer was estimated to have reached 330 000 worldwide. In the latest issue of Nature (6 April 2016), Seifert et al.
Shibata, K, Omahdi, Z, Yamasaki, S
openaire +2 more sources
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Cell Death and Disease, 2021 ABIN-1, also called TNIP1, is an ubiquitin-binding protein that serves an important role in suppressing RIPK1-independent apoptosis, necroptosis, and NF-κB activation. However, the involvement of ABIN-1 in the regulation of RIPK1-dependent apoptosis (RDA)
Jiali Cai +7 more
doaj +1 more source
Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
core +2 more sources
Nature CommunicationsPancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with dismal prognosis due to distant metastasis, even in the early stage. Using RNA sequencing and multiplex immunofluorescence, here we find elevated expression of mixed lineage kinase ...
Chengyu Liao +17 more
semanticscholar +1 more source
Roles of RIPK3 in necroptosis, cell signaling, and disease
Experimental and Molecular Medicine, 2022 Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis.
M. Morgan, You-Sun Kim
semanticscholar +1 more source