Results 91 to 100 of about 1,056 (174)

The role of nemolizumab in the treatment of atopic dermatitis for the adult population

Immunotherapy
Atopic dermatitis (AD) often requires long-term treatment that may be associated with adverse effects. This review aims to characterize nemolizumab as a treatment for AD in adults. A literature search was performed to assess nemolizumab's role in moderate-to-severe AD in adults.
Stuti Prajapati, Joseph P Flemming, Danyaal Khan, Haowei Han, Brian How, Suzanne Sirota Rozenberg, Steven R Feldman   +6 more
openaire   +3 more sources

672 - Nemolizumab monotherapy improves itch, sleep disturbance, and skin lesions in patients with moderate-to-severe prurigo nodularis: Pooled analyses from OLYMPIA 1 and OLYMPIA 2 phase 3 studies

Introduction Nemolizumab demonstrated clinically and statistically significant improvements in itch, sleep disturbance, and skin lesions in adults with moderate-to-severe prurigo nodularis (PN) in two phase 3 pivotal studies (OLYMPIA 1 [NCT04501666]1 and
Ahmed, Faiz, Sofen, Howard, Kwatra, Shawn G, Piketty, Christophe, Ständer, Sonja, Jabbar Lopez, Zarif K, Metz, Martin, Pink, Andrew E, Yosipovitch, Gil, Silverberg, Jonathan I, Noda, Aliene   +10 more
core   +1 more source

Role of IL-4 and IL-13 in Cutaneous T Cell Lymphoma

Life
The interleukins IL-4 and IL-13 are increasingly recognized contributors to the pathogenesis of cutaneous T cell lymphomas (CTCLs), and their role in disease-associated pruritus is accepted.
Roberto Mazzetto, Paola Miceli, Jacopo Tartaglia, Christian Ciolfi, Alvise Sernicola, Mauro Alaibac   +5 more
doaj   +1 more source

Efficacy and safety of different systemic drugs in the treatment of uremic pruritus among hemodialysis patients: a network meta-analysis based on randomized clinical trials

Frontiers in Medicine
AimThis network meta-analysis was to analyze and rank the efficacy and safety of different systemic drugs in the treatment of uremic pruritus (UP) among hemodialysis patients.MethodPubMed, Embase, Cochrane Library, and Web of Science databases were ...
Xueqian Zhao, Haipeng Sun, Wei Li
doaj   +1 more source

New and Emerging Biologics and Jak Inhibitors for the Treatment of Prurigo Nodularis: A Narrative Review

Medicina
Prurigo nodularis (PN) is a chronic dermatological condition characterized by intensely pruritic nodules resulting from repeated scratching. Its pathogenesis involves neuroimmune dysregulation, inflammatory cytokines, and neural proliferation ...
Matteo Bianco, Francesco D’Oria, Costanza Falcidia, Giulio Foggi, Elena Matteodo, Sara Di Giulio, Paola Facheris, Luciano Ibba, Chiara Perugini, Mario Valenti, Carlo Alberto Vignoli, Antonio Costanzo, Alessandra Narcisi, Luigi Gargiulo   +13 more
doaj   +1 more source

673 - Efficacy of nemolizumab in different subgroups of patients with prurigo nodularis in two randomized, placebo-controlled phase 3 trials

Introduction It is unknown whether baseline demographics and disease characteristics have an influence on efficacy and safety of nemolizumab in adults with moderate-to-severe prurigo nodularis (PN). Objectives To report safety and efficacy of nemolizumab
Gharib, Rola, Kwatra, Shawn G, Piketty, Christophe, Chen, Xiaoxiao, Jabbar Lopez, Zarif K, Ständer, Sonja, Metz, Martin, Sundaram, Hema, Pink, Andrew E, Yosipovitch, Gil, Noda, Aliene   +10 more
core   +1 more source

Chronic prurigo: current insights and future directions

Journal of the Egyptian Women’s Dermatologic Society
Chronic prurigo (CPG), particularly prurigo nodularis, is a highly burdensome skin disease that is characterized by the presence of chronic pruritus and hyperkeratotic, pruriginous papules and nodules.
Lea-Sophie Stahl, Sonja Ständer, Claudia Zeidler   +2 more
doaj   +1 more source

Dupilumab: an Additional Arrow in the Quiver for Prurigo Nodularis? Data From a Real-Life Setting

Dermatology Practical & Conceptual
Introduction: Prurigo nodularis (PN) management remains a significant challenge due to its chronicity, treatment resistance, and scarcity of approved treatments and to its impact on patients' quality of life.
Roberta Di Caprio, Stefano Caccavale, Eugenia Veronica Di Brizzi, Caterina Giorgio, Aleksandra Stefaniak, Giuseppe Argenziano, Anna Balato   +6 more
doaj   +1 more source

Nemolizumab elicits fast itch response in atopic dermatitis within 2 days: a post hoc analysis of ARCADIA 1 and 2 data

Background Itch is the most burdensome symptom of atopic dermatitis (AD) that severely affects sleep and overall and quality of life.1,2 Rapid control of itch could be instrumental in minimizing disease symptoms and the associated burden for patients.3,4
Yeon Cheong, Soo, Silverberg, Jonathan I, Piketty, Christophe, Papp, Kim A, Legat, Franz J, Pink, Andrew E, Thaçi, Diamant, Ulianov, Liliana, Laquer, Vivian T, Stein Gold, Linda F, Ryzhkova, Anna   +10 more
core   +1 more source

Diagnoses treated, medications tried and failed, and patient's response to itch or burning sensations following nemolizumab

Summary of patient demographics, diagnoses associated with pruritus, duration of skin disease, topical medication, phototherapy treatment, oral antihistamine, oral neuropathic agents, oral antibiotics, systemic anti-inflammatory therapy, number and ...
Dulai, Ajay
core   +1 more source