Results 91 to 100 of about 7,511 (210)

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, EarlyView.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

IgG subclasses and allotypes: from structure to effector functions

Frontiers in Immunology, 2014
Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains ...
Gestur eVidarsson, Gillian eDekkers, Theo eRispens   +2 more
doaj   +1 more source

Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source

A preliminary study of expression of human neonatal Fc-receptor (FcRn) in Escherichia coli

Asian Pacific Journal of Tropical Disease, 2014
Abstract Introduction Human neonatal Fc-receptor is a potential novel antibody binding protein for development of immunoassay. Previous studies had shown that this human protein has high affinity to Ig G either in vivo or in vitro. However, none of the studies had attempted exploring the utility of human FcRn in antibody immobilisation strategy.
W.K. Ng, Ngit Shin Lai, T.S. Limz
openaire   +2 more sources

Flow cytometry to assess the counts and physiological state of Cronobacter sakazakii cells after heat exposure [PDF]

arXiv, 2019
Cronobacter sakazakii is an opportunistic pathogen associated with outbreaks of neonatal necrotizing enterocolitis, septicemia, and meningitis. Reconstituted powdered infant formulae (PIF) is the most common vehicle of infection. Plate count methods do not provide direct information on the physiological status of cells.
arxiv  

Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds

Small, Volume 21, Issue 15, April 16, 2025.
Antibody‐nanomaterial conjugates (ANCs) are an emerging therapeutic class combining the precise targeting specificity of antibodies with the versatility and functionality of nanomaterials. This review summarizes ANC design, synthesis, and potential therapeutic applications in this rapidly advancing field.
Aniruddha Adhikari, Irene A. Chen
wiley   +1 more source

Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics

Frontiers in Immunology, 2015
The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism.
Kine Marita Knudsen Sand, Kine Marita Knudsen Sand, Malin eBern, Malin eBern, Jeannette eNilsen, Jeannette eNilsen, Hanna Theodora eNoordzij, Hanna Theodora eNoordzij, Inger eSandlie, Inger eSandlie, Jan Terje eAndersen   +10 more
doaj   +1 more source

An Introduction to Rule-based Modeling of Immune Receptor Signaling [PDF]

arXiv, 2017
Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory response) depending on the type and number of receptor molecules on the cell surface and the specific ...
arxiv  

Robust Neonatal Face Detection in Real-world Clinical Settings [PDF]

arXiv, 2022
Current face detection algorithms are extremely generalized and can obtain decent accuracy when detecting the adult faces. These approaches are insufficient when handling outlier cases, for example when trying to detect the face of a neonate infant whose face composition and expressions are relatively different than that of the adult. It is furthermore
arxiv  

Efficacy and Safety of Efgartigimod for Patients With Myasthenia Gravis in a Real‐World Cohort of 77 Patients

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
This real‐world study of 77 myasthenia gravis (MG) patients treated with efgartigimod showed rapid symptom improvement across disease severities. Sustained efficacy was achieved with repeated cycles, positioning efgartigimod as a promising MG therapy combining swift response and durable maintenance benefits. ABSTRACT Aims Efgartigimod, a first‐in‐class
Sijia Hao, Zhe Ruan, Rongjing Guo, Qingqing Wang, Xiaoxi Huang, Chao Sun, Huanhuan Li, Ting Gao, Yonglan Tang, Xiangqi Cao, Yu Liu, Zhuyi Li, Ting Chang   +12 more
wiley   +1 more source