Results 111 to 120 of about 7,511 (210)

Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

mAbs
Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn).
Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer   +3 more
doaj   +1 more source

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: Pharmacometrics & Systems Pharmacology, 2019
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster   +9 more
doaj   +1 more source

Neonatal EEG Interpretation and Decision Support Framework for Mobile Platforms [PDF]

arXiv, 2018
This paper proposes and implements an intuitive and pervasive solution for neonatal EEG monitoring assisted by sonification and deep learning AI that provides information about neonatal brain health to all neonatal healthcare professionals, particularly those without EEG interpretation expertise.
arxiv  

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn [PDF]

, 2010
Adam R. Mezo, Vandana Sridhar, John Badger, Paul Sakorafas, V. Nienaber   +4 more
openalex   +1 more source

Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport [PDF]

, 2011
Yu Bai, Lilin Ye, Devin B. Tesar, Haichen Song, Deming Zhao, Pamela J. Björkman, Derry C. Roopenian, Xiaoping Zhu   +7 more
openalex   +1 more source

Microbiota-dependent and -independent postnatal development of salivary immunity

Cell Reports, 2023
Summary: While saliva regulates the interplay between the microbiota and the oral immune system, the mechanisms establishing postnatal salivary immunity are ill-defined.
Khaled Zubeidat, Yasmin Jaber, Yasmin Saba, Or Barel, Reem Naamneh, Yasmin Netanely, Yael Horev, Luba Eli-berchoer, Amjad Shhadeh, Omri Yosef, Eliran Arbib, Gili Betser-Cohen, Chen Nadler, Hagit Shapiro, Eran Elinav, Doron J. Aframian, Asaf Wilensky, Avi-Hai Hovav   +17 more
doaj  

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

Biomolecules, 2018
Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated
Tommy Li, Joseph P. Balthasar
doaj   +1 more source

Firing Cell: An Artificial Neuron with a Simulation of Long-Term-Potentiation-Related Memory [PDF]

ISAROB 2006, pp.731-734, 2017
We propose a computational model of neuron, called firing cell (FC), properties of which cover such phenomena as attenuation of receptors for external stimuli, delay and decay of postsynaptic potentials, modification of internal weights due to propagation of postsynaptic potentials through the dendrite, modification of properties of the analog memory ...
arxiv  

Do neonates hear what we measure? Assessing neonatal ward soundscapes at the neonates ears [PDF]

Acoustic guidelines for neonatal intensive care units (NICUs) aim to protect vulnerable neonates from noise-induced physiological harm. However, the lack of recognised international standards for measuring neonatal soundscapes has led to inconsistencies in instrumentation and microphone placement in existing literature, raising concerns about the ...
arxiv   +1 more source