Results 61 to 70 of about 7,511 (210)

The neonatal Fc receptor expression during macrophage differentiation is related to autophagy

Frontiers in Immunology, 2022
The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy, Anthony Larue, Julie Mariot, Christine Dhommée, Marie-Véronique Demattei, Yves Delneste, Yves Delneste, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +8 more
doaj   +1 more source

Interactions of IgG1 CH2 and CH3 domains with FcRn

Frontiers in Immunology, 2014
Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, when compared to full-size antibodies, most of the current antibody fragments of VH or VL display greatly reduced
Tianlei eYing, Tina W Ju, Yanping eWang, Ponraj ePrabakaran, Dimiter S Dimitrov   +4 more
doaj   +1 more source

EffCRN: An Efficient Convolutional Recurrent Network for High-Performance Speech Enhancement [PDF]

arXiv, 2023
Fully convolutional recurrent neural networks (FCRNs) have shown state-of-the-art performance in single-channel speech enhancement. However, the number of parameters and the FLOPs/second of the original FCRN are restrictively high. A further important class of efficient networks is the CRUSE topology, serving as reference in our work.
arxiv  

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Predicting Adverse Neonatal Outcomes for Preterm Neonates with Multi-Task Learning [PDF]

arXiv, 2023
Diagnosis of adverse neonatal outcomes is crucial for preterm survival since it enables doctors to provide timely treatment. Machine learning (ML) algorithms have been demonstrated to be effective in predicting adverse neonatal outcomes. However, most previous ML-based methods have only focused on predicting a single outcome, ignoring the potential ...
arxiv  

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +1 more source

Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells

Experimental Eye Research, 2016
Retinal endothelial cells (REC) likely contribute to the clearance of intravitreally injected IgG. Because this is of high relevance to the pharmacokinetic assessment of the widely used therapeutic Fc fusion protein aflibercept, we studied its transport through immortalized bovine REC (iBREC) in detail.
Heidrun L. Deissler, Gerhard Lang, Gabriele E. Lang   +2 more
openalex   +4 more sources

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Impact of mAb-FcRn affinity on IgG transcytosis across human well-differentiated airway epithelium

Frontiers in Immunology
Effective treatment and immunoprophylaxis of viral respiratory infections with neutralizing monoclonal antibodies (mAbs) require maintaining inhibitory concentrations of mAbs at the airway surface.
Kohei Togami, Whitney Wolf, Lucas C. Olson, Madison Card, Limei Shen, Alison Schaefer, Kenichi Okuda, Larry Zeitlin, Michael Pauly, Kevin Whaley, Raymond J. Pickles, Raymond J. Pickles, Samuel K. Lai, Samuel K. Lai   +13 more
doaj   +1 more source