Results 61 to 70 of about 8,086 (233)

“Ways in which the neonatal Fc-receptor is involved in autoimmunity”

Journal of Translational Autoimmunity, 2021
Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses ...
Juliette Lamamy, Pierre Boulard, Guillaume Brachet, Sébastien Tourlet, Valérie Gouilleux-Gruart, Yanis Ramdani   +5 more
doaj   +1 more source

Expression of neonatal Fc receptor in the eye [PDF]

, 2014
PURPOSE: The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the bloodstream.
Christianson, G. J., Fruttiger, M., McKenzie, J. A. G., Powner, M. B., Roopenian, D. C.   +4 more
core   +1 more source

Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS [PDF]

, 2016
Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG
Doorn, P.A. (Pieter) van, Fokkink, W.-J.R. (Willem-Jan), Haarman, A.E.G. (Annechien E. G.), Huizinga, R. (Ruth), Jacobs, B.C. (Bart), Rijs, W. (Wouter) van, Tio-Gillen, A.P. (Anne)   +6 more
core   +1 more source

Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang, Wang Chonglong, Liu Zhengzhu, Xu Jingen, Fu Weixuan, Wang Wenwen, Ding Xiangdong, Liu Jianfeng, Zhang Qin   +8 more
doaj   +1 more source

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

mAbs, 2023
The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson, Jennifer R. Stratton   +13 more
doaj   +1 more source

Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn

PLoS ONE, 2012
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation. We have previously shown that overexpression of FcRn in transgenic mice significantly improves the humoral immune response.
Ana Paula Catunda Lemos, Judit Cervenak, Balázs Bender, Orsolya Ivett Hoffmann, Mária Baranyi, Andrea Kerekes, Anita Farkas, Zsuzsanna Bösze, László Hiripi, Imre Kacskovıcs   +9 more
openalex   +7 more sources

Selection of IgG variants with increased FcRn binding using random and directed mutagenesis: impact on effector functions

Frontiers in Immunology, 2015
Despite the reasonably long half-life of IgGs, market pressure for higher patient convenience while conserving efficacy continues to drive IgG half-life improvement.
Céline eMonnet, Sylvie eJorieux, Nathalie eFournier, Rémi eUrbain, Khalil eBouayadi, Christophe eDe Romeuf, Christian K Behrens, Alexandre eFontayne, Philippe eMondon   +8 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity [PDF]

, 2012
The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense.
Blumberg, Richard Steven, Frank, Scott Randy, Goldenring, James R., Hamman, Wendy, Hansen, Steen Henning, Lapierre, Lynne A., Lencer, Wayne Isaac, Massol, Ramiro, Tzaban, Salit, Yen, Elizabeth Hechavarria   +9 more
core   +1 more source

Engineered clearing agents for the selective depletion of antigen-specific antibodies

Nature Communications, 2017
The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to ...
Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward   +4 more
doaj   +1 more source