Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models [PDF]
Scientific ReportsPathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal
Allyssa Bradley +9 more
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Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity [PDF]
FASEB BioAdvancesVascular endothelial growth factor (VEGF) is important in both developmental and pathologic angiogenesis in retinopathy of prematurity (ROP). Using a rat model representative of ROP, we found that regulation of VEGF signaling through VEGF receptor 2 ...
Aniket Ramshekar +10 more
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Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
, 2013 We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary +6 more
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Frontiers in Pediatrics, 2021 Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj +1 more source
TNF-alpha increases angiogenic potential in a co-culture system of dental pulp cells and endothelial cells [PDF]
Brazilian Oral Research, 2019 We recently demonstrated that a co-culture system of human umbilical vein endothelial cells (HUVECs) and human dental pulp stem cells (hDPSCs) could enhance angiogenesis ability in vitro.
Li AN +6 more
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Angiogenic effects of cryosurgery with liquid nitrogen on the normal skin of rats, through morphometric study [PDF]
Anais Brasileiros de Dermatologia, 2014 BACKGROUND:Cryosurgery is an efficient therapeutic technique used to treat benign and malignant cutaneous diseases. The primary active mechanism of cryosurgery is related to vascular effects on treated tissue.
Camila Bianco Pimentel +2 more
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Roles of lipocalin-type and hematopoietic prostaglandin D synthases in mouse retinal angiogenesis
Journal of Lipid Research, 2023 Normal angiogenesis is essential for retinal development and maintenance of visual function in the eye, and its abnormality can cause retinopathy and other eye diseases. Prostaglandin D2 is an anti-angiogenic lipid mediator produced by lipocalin-type PGD
Daiki Horikami +8 more
doaj +1 more source
Case Reports in Ophthalmological Medicine, 2022 Purpose. To describe a case of open-angle neovascular glaucoma (NVG) secondary to ocular ischemic syndrome (OIS) treated with a planned series of 6 monthly anti-VEGF injections with interspersed panretinal photocoagulation (PRP) sessions.
Hassaan Asif +7 more
doaj +1 more source
Biological Procedures Online, 2010 The aim of this study was to compare different cell sources and culture conditions to obtain endothelial progenitor cells (EPCs) with predictable antigen pattern, proliferation potential and in vitro vasculogenesis.
Muscari Claudio +7 more
doaj +3 more sources
Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme [PDF]
, 2015 Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited.
Chan, Cecilia W. S +3 more
core +1 more source