Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models [PDF]
Scientific ReportsPathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal
Allyssa Bradley +9 more
doaj +2 more sources
Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity [PDF]
FASEB BioAdvancesVascular endothelial growth factor (VEGF) is important in both developmental and pathologic angiogenesis in retinopathy of prematurity (ROP). Using a rat model representative of ROP, we found that regulation of VEGF signaling through VEGF receptor 2 ...
Aniket Ramshekar +10 more
doaj +2 more sources
Frontiers in Pediatrics, 2021 Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj +1 more source
Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
, 2013 We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary +6 more
core +8 more sources
TNF-alpha increases angiogenic potential in a co-culture system of dental pulp cells and endothelial cells [PDF]
Brazilian Oral Research, 2019 We recently demonstrated that a co-culture system of human umbilical vein endothelial cells (HUVECs) and human dental pulp stem cells (hDPSCs) could enhance angiogenesis ability in vitro.
Li AN +6 more
doaj +1 more source
Angiogenic effects of cryosurgery with liquid nitrogen on the normal skin of rats, through morphometric study [PDF]
Anais Brasileiros de Dermatologia, 2014 BACKGROUND:Cryosurgery is an efficient therapeutic technique used to treat benign and malignant cutaneous diseases. The primary active mechanism of cryosurgery is related to vascular effects on treated tissue.
Camila Bianco Pimentel +2 more
doaj +2 more sources
Physiological MRI of microvascular architecture, neovascularization activity, and oxygen metabolism facilitate early recurrence detection in patients with IDH-mutant WHO grade 3 glioma [PDF]
Neuroradiology, 2021 Abstract Purpose This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma. Methods
Andreas Stadlbauer +8 more
openaire +3 more sources
Roles of lipocalin-type and hematopoietic prostaglandin D synthases in mouse retinal angiogenesis
Journal of Lipid Research, 2023 Normal angiogenesis is essential for retinal development and maintenance of visual function in the eye, and its abnormality can cause retinopathy and other eye diseases. Prostaglandin D2 is an anti-angiogenic lipid mediator produced by lipocalin-type PGD
Daiki Horikami +8 more
doaj +1 more source
Proangiogenic cells enhanced persistent and physiologic neovascularization compared with macrophages [PDF]
Experimental & Molecular Medicine, 2015 Proangiogenic cells (PACs) display surface markers and secrete angiogenic factors similar to those used by myelomonocytic cells, but, unlike myelomonocytic cells, PACs enhance neovascularization activity in experimental ischemic diseases. This study was performed to reveal the differential neovascularization activities of PACs compared with those of ...
Choi, Young-Eun +4 more
openaire +2 more sources
Case Reports in Ophthalmological Medicine, 2022 Purpose. To describe a case of open-angle neovascular glaucoma (NVG) secondary to ocular ischemic syndrome (OIS) treated with a planned series of 6 monthly anti-VEGF injections with interspersed panretinal photocoagulation (PRP) sessions.
Hassaan Asif +7 more
doaj +1 more source