Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models [PDF]
Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal
Allyssa Bradley +9 more
doaj +2 more sources
Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity [PDF]
Vascular endothelial growth factor (VEGF) is important in both developmental and pathologic angiogenesis in retinopathy of prematurity (ROP). Using a rat model representative of ROP, we found that regulation of VEGF signaling through VEGF receptor 2 ...
Aniket Ramshekar +10 more
doaj +2 more sources
Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary +6 more
core +8 more sources
Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj +1 more source
TNF-alpha increases angiogenic potential in a co-culture system of dental pulp cells and endothelial cells [PDF]
We recently demonstrated that a co-culture system of human umbilical vein endothelial cells (HUVECs) and human dental pulp stem cells (hDPSCs) could enhance angiogenesis ability in vitro.
Li AN +6 more
doaj +1 more source
Angiogenic effects of cryosurgery with liquid nitrogen on the normal skin of rats, through morphometric study [PDF]
BACKGROUND:Cryosurgery is an efficient therapeutic technique used to treat benign and malignant cutaneous diseases. The primary active mechanism of cryosurgery is related to vascular effects on treated tissue.
Camila Bianco Pimentel +2 more
doaj +2 more sources
Roles of lipocalin-type and hematopoietic prostaglandin D synthases in mouse retinal angiogenesis
Normal angiogenesis is essential for retinal development and maintenance of visual function in the eye, and its abnormality can cause retinopathy and other eye diseases. Prostaglandin D2 is an anti-angiogenic lipid mediator produced by lipocalin-type PGD
Daiki Horikami +8 more
doaj +1 more source
Purpose. To describe a case of open-angle neovascular glaucoma (NVG) secondary to ocular ischemic syndrome (OIS) treated with a planned series of 6 monthly anti-VEGF injections with interspersed panretinal photocoagulation (PRP) sessions.
Hassaan Asif +7 more
doaj +1 more source
The aim of this study was to compare different cell sources and culture conditions to obtain endothelial progenitor cells (EPCs) with predictable antigen pattern, proliferation potential and in vitro vasculogenesis.
Muscari Claudio +7 more
doaj +3 more sources
Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme [PDF]
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited.
Chan, Cecilia W. S +3 more
core +1 more source

