Results 21 to 30 of about 16,236 (238)

T2-TrpRS Inhibits Preretinal Neovascularization and Enhances Physiological Vascular Regrowth in OIR as Assessed by a New Method of Quantification

Investigative Opthalmology & Visual Science, 2006
A carboxyl-terminal fragment of tryptophan tRNA synthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovascularization in vivo. The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR).C57BL/6J ...
Eyal, Banin, Michael I, Dorrell, Edith, Aguilar, Matthew R, Ritter, Christopher M, Aderman, Alexandra C H, Smith, Jeffrey, Friedlander, Martin, Friedlander   +7 more
openaire   +2 more sources

Epoxyeicosanoids promote organ and tissue regeneration [PDF]

, 2013
Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone.
Mudge, Dayna K, Falck, John R, Butterfield, Catherine E, Le, Hau D, Tomer, Kenneth B, D’Amore, Patricia A, Lee, Craig R, Manthati, Vijaya L, Edin, Matthew L, Inceoglu, Bora, Zeldin, Darryl C, Kalish, Brian T, Bielenberg, Diane R, Kaipainen, Arja, Hammock, Bruce D, Panigrahy, Dipak, Yang, Jun, Mammoto, Tadanori, Huang, Sui, Jenkins, Roger L, Simpson, Mary A, Puder, Mark, Akino, Tomoshige, Mammoto, Akiko, Benny, Ofra, Lih, Fred B, Ingber, Donald E, Kieran, Mark W   +27 more
core   +4 more sources

Induction of Neovascularization by Activated Human Monocytes

, 1986
Neovascularization, the process of new blood vessel growth, is an important feature of many pathologic and physiologic processes. Monocytes were isolated from citrated blood buffy coat of healthy adult human donors on Ficoll-Hypaque gradients ...
Peter J Polverini, Alisa E Koch, S Joseph Leibovich   +2 more
core   +1 more source

Effect of endogenous bone marrow derived stem cells induced by AMD-3100 on expanded ischemic flap. [PDF]

, 2014
The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming its effect on mobilization of stem cells from the bone marrow.
정희선, 탁관철, 유대현, 고윤우, 김철훈   +4 more
core   +1 more source

Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR [PDF]

, 2020
PURPOSE. The efficacy of three matrix metalloproteinase (MMP) inhibitors with various selectivities (Ro-31-9790, AG3340, and DPC-A37668) was investigated in a rat model of retinopathy of prematurity, to examine the roles of MMP-2 and -9 in retinal ...
Myers Squibb, Bristol-Myers Squibb, John S Penn, James, ; D P Bingaman, F, None; J D Kay, Jesse D Kay, Gary W Mccollum, Alcon, David P Bingaman, R.-Q Liu, Joshua M Barnett, Rui-Qin Liu, Jessica A Fowler, J.-W Duan   +15 more
core  

Targeting VEGF in eye neovascularization: What's new? A comprehensive review on current therapies and oligonucleotide-based interventions under development

, 2016
Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the treatment of neovascular AMD and other eye pathologies characterized by ocular neoangiogenesis.
Stefano Govoni, Govoni, Stefano, PASCALE, ALESSIA ANGELA, Marialaura Amadio, Alessia Pascale, Amadio, Marialaura, Pascale, Alessia   +6 more
core   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma

, 2017
Dopamine is a catecholamine that acts both as a neurotransmitter and as a hormone, exerting its functions via dopamine (DA) receptors that are present in a broad variety of organs and cells throughout the body.
Horst-Schrivers, van der, Anouk, Thamara E. Osinga, Osinga, Thamara E, Dullaart, Robin P F, Pacak, Karel, Karel Pacak, Links, Thera P, Anouk N. A. Horst‐Schrivers, Kema, Ido P, Michiel N. Kerstens, Kema, Ido P; id_orcid, Ido P. Kema, Kerstens, Michiel N., Robin P. F. Dullaart, Thera P. Links   +14 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Neovascularization and recurrent varicose veins: more histologic and ultrasound evidence

, 2004
BackgroundThe recurrence of varicose veins is a common and costly consequence of varicose vein surgery. Despite the long history and vast experience of varicose vein surgery, the exact cause of recurrence is still unknown.
Jones, Gregory T, van Rij, André M, Jiang, Ping, Hill, Gerry B   +3 more
core   +1 more source