Results 21 to 30 of about 97,146 (264)

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy [PDF]

Journal of Biological Chemistry, 2011
Retinal vascular damages are the cardinal hallmarks of retinopathy of prematurity (ROP), a leading cause of vision impairment and blindness in childhood. Both angiogenesis and vasculogenesis are disrupted in the hyperoxia-induced vaso-obliteration phase, and recapitulated, although aberrantly, in the subsequent ischemia-induced neovessel formation ...
Adeel, Hasan, Nataliya, Pokeza, Lynn, Shaw, Hyun-Seung, Lee, Douglas, Lazzaro, Hemabindu, Chintala, Daniel, Rosenbaum, Maria B, Grant, Brahim, Chaqour   +8 more
openaire   +2 more sources

miR‐30a‐5p inhibition promotes interaction of Fas⁺endothelial cells and FasL⁺microglia to decrease pathological neovascularization and promote physiological angiogenesis [PDF]

Glia, 2018
AbstractIschemia‐induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti‐VEGF agents but are not successful in all cases. In this study we determined that miR‐30a‐5p is another important mediator of retinal angiogenesis.
Salome Murinello, Yoshihiko Usui, Susumu Sakimoto, Maki Kitano, Edith Aguilar, H. Maura Friedlander, Amelia Schricker, Carli Wittgrove, Yoshihiro Wakabayashi, Michael I. Dorrell, Peter D. Westenskow, Martin Friedlander   +11 more
openaire   +2 more sources

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis [PDF]

, 2009
Background Endothelium-derived nitric oxide plays an important role for the bone marrow microenvironment. Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector ...
Feil, Robert, Hofmann, Franz, Alexandra Aicher, Michael E. Mendelsohn, Aicher, Alexandra, Michael E Mendelsohn, Mendelsohn, Michael E., Alexandra Aicher, Heeschen, Christopher, Feil, Susanne, Christopher Heeschen, Stefanie Dimmeler, Dimmeler, Stefanie, Franz Hofmann, Susanne Feil, Robert Feil   +15 more
core   +2 more sources

Intense Physiological Light Upregulates Vascular Endothelial Growth Factor and Enhances Choroidal Neovascularization via Peroxisome Proliferator-Activated Receptor γ Coactivator-1α in Mice [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objectives— Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear. Methods and Results— Effects of intense, but within physiological range, light on ...
Takashi, Ueta, Tatsuya, Inoue, Kentaro, Yuda, Takahisa, Furukawa, Yasuo, Yanagi, Yasuhiro, Tamaki   +5 more
openaire   +2 more sources

Selective Suppression of Pathologic, but Not Physiologic, Retinal Neovascularization by Blocking the Angiotensin II Type 1 Receptor

Investigative Opthalmology & Visual Science, 2005
To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization.C57BL/6 neonatal mice were reared in an 80% concentration of oxygen from postnatal day (P)7 to P12, followed by room-air breathing until P17, to induce ischemia-initiated ...
Norihiro, Nagai, Kousuke, Noda, Takashi, Urano, Yoshiaki, Kubota, Hajime, Shinoda, Takashi, Koto, Kei, Shinoda, Makoto, Inoue, Takayuki, Shiomi, Eiji, Ikeda, Kazuo, Tsubota, Toshio, Suda, Yuichi, Oike, Susumu, Ishida   +13 more
openaire   +2 more sources

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
David-Alexandre Tregouet (4350982), Florian Sennlaub (64439), Xavier Guillonneau, William Raoul (64427), Sophie Krumeich (177422), Sophie Krumeich, Raoul William, Théry Clotilde, Calippe Bertrand, Salomon-Yves Cohen, Poupel Lucie, Camelo, Serge, Xavier Guillonneau (64430), Bertrand Calippe, Behar-Cohen Francine, Tregouet, David-Alexandre, Baatz, Holger, Bertrand Calippe (177425), Florian Sennlaub, Lucie Poupel, Francine Behar-Cohen, Théry, Clotilde, Sophie Lavalette (64428), Serge Camelo (177419), Calippe, Bertrand, Cohen Salomon-Yves, Lavalette Sophie, Behar-Cohen, Francine, Clotilde Théry (177438), Lavalette, Sophie, Tregouet David-Alexandre, Christophe Combadière, Combadière Christophe, Raoul, William, William Raoul, Sennlaub Florian, Salomon-Yves Cohen (177429), Baatz Holger, Guillonneau, Xavier, Nicole Keller, Keller, Nicole, Guillonneau Xavier, Camelo Serge, Nicole Keller (64429), Keller Nicole, Cohen, Salomon-Yves, David-Alexandre Tregouet, Serge Camelo, Sophie Lavalette, Holger Baatz (177431), Krumeich Sophie, Christophe Combadière (177434), Sennlaub, Florian, Combadière, Christophe, Poupel, Lucie, Krumeich, Sophie, Lucie Poupel (177410), Holger Baatz, Clotilde Théry, Francine Behar-Cohen (64434), Behar-Cohen, F., Krumeich, S., Camelo, S., Combadière, C., Guillonneau, X., Baatz, H., Sennlaub, F., Calippe, B., Poupel, L., Théry, C., Keller, N., Lavalette, S., Cohen, S.Y., Tregouet, D.A., Raoul, W.   +74 more
core   +1 more source

Wearable physiologic monitoring in healthcare simulation

, 2023
The ability to non-invasively monitor physiological changes in healthcare providers in simulation settings is important as it can provide insights into the hidden internal states of individuals.
MacQuarrie, Alex, Stainer, Matt, Deetlefs, Chloe, Sidhu, Jasmin, Matt Stainer, Chloe Deetlefs, Alex MacQuarrie, Jasmin Sidhu   +7 more
core   +1 more source

Quantitative physiological measurements to evaluate the response of antivascular endothelial growth factor treatment in patients with neovascular diseases

Indian Journal of Ophthalmology, 2017
Antivascular endothelial growth factor (VEGF) treatment is still used intravitreally worldwide for various neovascular diseases, despite other available, approved treatments. We performed a systematic search of the literature focused on visual physiology studies.
In Hwan Hong, Sung Pyo Park
openaire   +3 more sources

T2-TrpRS Inhibits Preretinal Neovascularization and Enhances Physiological Vascular Regrowth in OIR as Assessed by a New Method of Quantification

Investigative Opthalmology & Visual Science, 2006
A carboxyl-terminal fragment of tryptophan tRNA synthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovascularization in vivo. The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR).C57BL/6J ...
Eyal, Banin, Michael I, Dorrell, Edith, Aguilar, Matthew R, Ritter, Christopher M, Aderman, Alexandra C H, Smith, Jeffrey, Friedlander, Martin, Friedlander   +7 more
openaire   +2 more sources

Angiogenic activity of Calendula officinalis flowers L. in rats Atividade angiogênica das flores da Calendula officinalis L. em ratos

Acta Cirúrgica Brasileira, 2011
Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant ...
Leila Maria Leal Parente, Maria Auxiliadora Andrade, Luiz Augusto Batista Brito, Veridiana Maria Brianezi Dignani de Moura, Marina Pacheco Miguel, Ruy de Souza Lino-Júnior, Leonice Faustino Manrique Tresvenzol, José Realino de Paula, Neusa Margarida Paulo   +8 more
doaj   +1 more source