Results 21 to 30 of about 16,333 (259)

Inhibition of Tumor Necrosis Factor-α Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy [PDF]

The American Journal of Pathology, 2005
The present study was undertaken to test whether inhibition of the proangiogenic inflammatory cytokine tumor necrosis factor (TNF)-alpha can modulate retinal hypoxia and preretinal neovascularization in a murine model of oxygen-induced retinopathy (OIR).
Gardiner, T A, Gibson, D S, de Gooyer, T E, de la Cruz, V F, McDonald, D M, Stitt, A W   +5 more
openaire   +2 more sources

Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage

Biological Procedures Online, 2010
The aim of this study was to compare different cell sources and culture conditions to obtain endothelial progenitor cells (EPCs) with predictable antigen pattern, proliferation potential and in vitro vasculogenesis.
Muscari Claudio, Gamberini Chiara, Basile Ilaria, Bonafé Francesca, Valgimigli Simond, Capitani Ombretta, Guarnieri Carlo, Caldarera Claudio   +7 more
doaj   +3 more sources

Synchrotron Radiation Coronary Microangiography for Morphometric and Physiological Evaluation of Myocardial Neovascularization Induced by Endothelial Progenitor Cell Transplantation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Background— Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals. However, it has been technically difficult to obtain imaging evidence of collateral formation by conventional angiography.
Hiroto, Iwasaki, Kazuhito, Fukushima, Atsuhiko, Kawamoto, Keiji, Umetani, Akira, Oyamada, Saeko, Hayashi, Tomoyuki, Matsumoto, Masakazu, Ishikawa, Toshihiko, Shibata, Hiromi, Nishimura, Hidekazu, Hirai, Yutaka, Mifune, Miki, Horii, Kazuro, Sugimura, Shigefumi, Suehiro, Takayuki, Asahara   +15 more
openaire   +2 more sources

Induction of Neovascularization by Activated Human Monocytes [PDF]

, 1986
Neovascularization, the process of new blood vessel growth, is an important feature of many pathologic and physiologic processes. Monocytes were isolated from citrated blood buffy coat of healthy adult human donors on Ficoll-Hypaque gradients ...
Peter J Polverini, Alisa E Koch, S Joseph Leibovich   +2 more
core   +1 more source

Targeting VEGF in eye neovascularization: What's new? A comprehensive review on current therapies and oligonucleotide-based interventions under development [PDF]

, 2016
Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the treatment of neovascular AMD and other eye pathologies characterized by ocular neoangiogenesis.
Stefano Govoni, Govoni, Stefano, PASCALE, ALESSIA ANGELA, Marialaura Amadio, Alessia Pascale, Amadio, Marialaura, Pascale, Alessia   +6 more
core   +1 more source

Pathological but Not Physiological Retinal Neovascularization Is Altered in TNF-Rp55-Receptor–Deficient Mice

Investigative Opthalmology & Visual Science, 2006
Tumor necrosis factor (TNF)-alpha is one of the major cytokines in inflammation and apoptosis. It has been demonstrated that inhibition of TNFalpha can reduce leukocyte adhesion, vascular leakage, and apoptotic endothelial cell death in diabetes. This study was conducted to investigate the effect of TNF-Rp55 and TNF-Rp75 on retinal development in ...
Norbert, Kociok, Sven, Radetzky, Tim U, Krohne, Claudia, Gavranic, Antonia M, Joussen   +4 more
openaire   +2 more sources

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy [PDF]

Journal of Biological Chemistry, 2011
Retinal vascular damages are the cardinal hallmarks of retinopathy of prematurity (ROP), a leading cause of vision impairment and blindness in childhood. Both angiogenesis and vasculogenesis are disrupted in the hyperoxia-induced vaso-obliteration phase, and recapitulated, although aberrantly, in the subsequent ischemia-induced neovessel formation ...
Adeel, Hasan, Nataliya, Pokeza, Lynn, Shaw, Hyun-Seung, Lee, Douglas, Lazzaro, Hemabindu, Chintala, Daniel, Rosenbaum, Maria B, Grant, Brahim, Chaqour   +8 more
openaire   +2 more sources

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma [PDF]

, 2017
Dopamine is a catecholamine that acts both as a neurotransmitter and as a hormone, exerting its functions via dopamine (DA) receptors that are present in a broad variety of organs and cells throughout the body.
Horst-Schrivers, van der, Anouk, Thamara E. Osinga, Osinga, Thamara E, Dullaart, Robin P F, Pacak, Karel, Karel Pacak, Links, Thera P, Anouk N. A. Horst‐Schrivers, Kema, Ido P, Michiel N. Kerstens, Kema, Ido P; id_orcid, Ido P. Kema, Kerstens, Michiel N., Robin P. F. Dullaart, Thera P. Links   +14 more
core   +1 more source

miR‐30a‐5p inhibition promotes interaction of Fas⁺endothelial cells and FasL⁺microglia to decrease pathological neovascularization and promote physiological angiogenesis [PDF]

Glia, 2018
AbstractIschemia‐induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti‐VEGF agents but are not successful in all cases. In this study we determined that miR‐30a‐5p is another important mediator of retinal angiogenesis.
Salome Murinello, Yoshihiko Usui, Susumu Sakimoto, Maki Kitano, Edith Aguilar, H. Maura Friedlander, Amelia Schricker, Carli Wittgrove, Yoshihiro Wakabayashi, Michael I. Dorrell, Peter D. Westenskow, Martin Friedlander   +11 more
openaire   +2 more sources

Neovascularization and recurrent varicose veins: more histologic and ultrasound evidence [PDF]

, 2004
BackgroundThe recurrence of varicose veins is a common and costly consequence of varicose vein surgery. Despite the long history and vast experience of varicose vein surgery, the exact cause of recurrence is still unknown.
Jones, Gregory T, van Rij, André M, Jiang, Ping, Hill, Gerry B   +3 more
core   +1 more source