Results 11 to 20 of about 21,633 (255)

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization [PDF]

The Journal of Experimental Medicine, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF164 increased to
Ishida, Susumu, Usui, Tomohiko, Yamashiro, Kenji, Kaji, Yuichi, Amano, Shiro, Ogura, Yuichiro, Hida, Tetsuo, Oguchi, Yoshihisa, Ambati, Jayakrishna, Miller, Joan, Gragoudas, Evangelos, Ng, Yin-Shan, D'Amore, Patricia, Shima, David T., Adamis, Anthony   +14 more
openaire   +4 more sources

Inhibition of Tumor Necrosis Factor-α Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy [PDF]

The American Journal of Pathology, 2005
The present study was undertaken to test whether inhibition of the proangiogenic inflammatory cytokine tumor necrosis factor (TNF)-alpha can modulate retinal hypoxia and preretinal neovascularization in a murine model of oxygen-induced retinopathy (OIR).
Gardiner, T A, Gibson, D S, de Gooyer, T E, de la Cruz, V F, McDonald, D M, Stitt, A W   +5 more
openaire   +2 more sources

Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization [PDF]

Circulation Research, 1999
Abstract —Circulating endothelial progenitor cells (EPCs) have been isolated in peripheral blood of adult species. To determine the origin and role of EPCs contributing to postnatal vasculogenesis, transgenic mice constitutively expressing β-galactosidase under the transcriptional regulation of an endothelial cell–specific ...
T, Asahara, H, Masuda, T, Takahashi, C, Kalka, C, Pastore, M, Silver, M, Kearne, M, Magner, J M, Isner   +8 more
openaire   +2 more sources

Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage

Biological Procedures Online, 2010
The aim of this study was to compare different cell sources and culture conditions to obtain endothelial progenitor cells (EPCs) with predictable antigen pattern, proliferation potential and in vitro vasculogenesis.
Muscari Claudio, Gamberini Chiara, Basile Ilaria, Bonafé Francesca, Valgimigli Simond, Capitani Ombretta, Guarnieri Carlo, Caldarera Claudio   +7 more
doaj   +3 more sources

Synchrotron Radiation Coronary Microangiography for Morphometric and Physiological Evaluation of Myocardial Neovascularization Induced by Endothelial Progenitor Cell Transplantation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Background— Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals. However, it has been technically difficult to obtain imaging evidence of collateral formation by conventional angiography.
Hiroto, Iwasaki, Kazuhito, Fukushima, Atsuhiko, Kawamoto, Keiji, Umetani, Akira, Oyamada, Saeko, Hayashi, Tomoyuki, Matsumoto, Masakazu, Ishikawa, Toshihiko, Shibata, Hiromi, Nishimura, Hidekazu, Hirai, Yutaka, Mifune, Miki, Horii, Kazuro, Sugimura, Shigefumi, Suehiro, Takayuki, Asahara   +15 more
openaire   +2 more sources

Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme [PDF]

, 2015
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited.
Chan, Cecilia W. S, Kaplan, Warren, Khachigian, Levon M, Parish, Christopher   +3 more
core   +1 more source

eNOS transfection of adipose-derived stem cells yields bioactive nitric oxide production and improved results in vascular tissue engineering. [PDF]

, 2015
This study evaluates the durability of a novel tissue engineered blood vessel (TEBV) created by seeding a natural vascular tissue scaffold (decellularized human saphenous vein allograft) with autologous adipose-derived stem cells (ASC) differentiated ...
Bagameri, Gabor, Comeau, Jason, DiMuzio, Paul J., Faul, Elizabeth J, Fernandez, Sarah, Ferroni, Matthew, McIlhenny, Stephen, Policha, Aleksandra, Shapiro, Irving, Tulenko, Thomas, Zhang, Ping   +10 more
core   +2 more sources

Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis. The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.C57BL/6 neonatal mice ...
Shingo, Satofuka, Atsuhiro, Ichihara, Norihiro, Nagai, Takashi, Koto, Hajime, Shinoda, Kousuke, Noda, Yoko, Ozawa, Makoto, Inoue, Kazuo, Tsubota, Hiroshi, Itoh, Yuichi, Oike, Susumu, Ishida   +11 more
openaire   +2 more sources

Intense Physiological Light Upregulates Vascular Endothelial Growth Factor and Enhances Choroidal Neovascularization via Peroxisome Proliferator-Activated Receptor γ Coactivator-1α in Mice [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objectives— Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear. Methods and Results— Effects of intense, but within physiological range, light on ...
Takashi, Ueta, Tatsuya, Inoue, Kentaro, Yuda, Takahisa, Furukawa, Yasuo, Yanagi, Yasuhiro, Tamaki   +5 more
openaire   +2 more sources

Vaginal rejuvenation using energy-based devices

International Journal of Women's Dermatology, 2016
Physiologic changes in a woman’s life, such as childbirth, weight fluctuations, and hormonal changes due to aging and menopause, may alter the laxity of the vaginal canal, damage the pelvic floor, and devitalize the mucosal tone of the vaginal wall ...
Cheryl Karcher, MD, Neil Sadick, MD
doaj   +1 more source