Results 11 to 20 of about 1,820,535 (282)

Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis. The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.C57BL/6 neonatal mice ...
Shingo, Satofuka, Atsuhiro, Ichihara, Norihiro, Nagai, Takashi, Koto, Hajime, Shinoda, Kousuke, Noda, Yoko, Ozawa, Makoto, Inoue, Kazuo, Tsubota, Hiroshi, Itoh, Yuichi, Oike, Susumu, Ishida   +11 more
openaire   +3 more sources

Selective Suppression of Pathologic, but Not Physiologic, Retinal Neovascularization by Blocking the Angiotensin II Type 1 Receptor

Investigative Opthalmology & Visual Science, 2005
To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization.C57BL/6 neonatal mice were reared in an 80% concentration of oxygen from postnatal day (P)7 to P12, followed by room-air breathing until P17, to induce ischemia-initiated ...
Norihiro, Nagai, Kousuke, Noda, Takashi, Urano, Yoshiaki, Kubota, Hajime, Shinoda, Takashi, Koto, Kei, Shinoda, Makoto, Inoue, Takayuki, Shiomi, Eiji, Ikeda, Kazuo, Tsubota, Toshio, Suda, Yuichi, Oike, Susumu, Ishida   +13 more
openaire   +3 more sources

Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI

Metabolites, 2021
The tumor microenvironment is a critical regulator of cancer development and progression as well as treatment response and resistance in brain neoplasms.
A. Stadlbauer, F. Marhold, S. Oberndorfer, G. Heinz, Max Zimmermann, M. Buchfelder, E. Heynold, T. Kinfe   +7 more
semanticscholar   +1 more source

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization [PDF]

The Journal of Experimental Medicine, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF164 increased to
Ishida, Susumu, Usui, Tomohiko, Yamashiro, Kenji, Kaji, Yuichi, Amano, Shiro, Ogura, Yuichiro, Hida, Tetsuo, Oguchi, Yoshihisa, Ambati, Jayakrishna, Miller, Joan, Gragoudas, Evangelos, Ng, Yin-Shan, D'Amore, Patricia, Shima, David T., Adamis, Anthony   +14 more
openaire   +4 more sources

Inhibition of Tumor Necrosis Factor-α Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy [PDF]

The American Journal of Pathology, 2005
The present study was undertaken to test whether inhibition of the proangiogenic inflammatory cytokine tumor necrosis factor (TNF)-alpha can modulate retinal hypoxia and preretinal neovascularization in a murine model of oxygen-induced retinopathy (OIR).
Gardiner, T A, Gibson, D S, de Gooyer, T E, de la Cruz, V F, McDonald, D M, Stitt, A W   +5 more
openaire   +2 more sources

Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization [PDF]

Circulation Research, 1999
Abstract —Circulating endothelial progenitor cells (EPCs) have been isolated in peripheral blood of adult species. To determine the origin and role of EPCs contributing to postnatal vasculogenesis, transgenic mice constitutively expressing β-galactosidase under the transcriptional regulation of an endothelial cell–specific ...
T, Asahara, H, Masuda, T, Takahashi, C, Kalka, C, Pastore, M, Silver, M, Kearne, M, Magner, J M, Isner   +8 more
openaire   +2 more sources

Physiologic MR imaging of the tumor microenvironment revealed switching of metabolic phenotype upon recurrence of glioblastoma in humans

Journal of Cerebral Blood Flow and Metabolism, 2020
Treating recurrent glioblastoma (GB) is one of the challenges in modern neurooncology. Hypoxia, neovascularization, and energy metabolism are of crucial importance for therapy failure and recurrence.
A. Stadlbauer, S. Oberndorfer, Max Zimmermann, B. Renner, M. Buchfelder, G. Heinz, A. Doerfler, A. Kleindienst, K. Roessler   +8 more
semanticscholar   +1 more source

Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage

Biological Procedures Online, 2010
The aim of this study was to compare different cell sources and culture conditions to obtain endothelial progenitor cells (EPCs) with predictable antigen pattern, proliferation potential and in vitro vasculogenesis.
Muscari Claudio, Gamberini Chiara, Basile Ilaria, Bonafé Francesca, Valgimigli Simond, Capitani Ombretta, Guarnieri Carlo, Caldarera Claudio   +7 more
doaj   +3 more sources

Synchrotron Radiation Coronary Microangiography for Morphometric and Physiological Evaluation of Myocardial Neovascularization Induced by Endothelial Progenitor Cell Transplantation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Background— Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals. However, it has been technically difficult to obtain imaging evidence of collateral formation by conventional angiography.
Hiroto, Iwasaki, Kazuhito, Fukushima, Atsuhiko, Kawamoto, Keiji, Umetani, Akira, Oyamada, Saeko, Hayashi, Tomoyuki, Matsumoto, Masakazu, Ishikawa, Toshihiko, Shibata, Hiromi, Nishimura, Hidekazu, Hirai, Yutaka, Mifune, Miki, Horii, Kazuro, Sugimura, Shigefumi, Suehiro, Takayuki, Asahara   +15 more
openaire   +2 more sources

Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme [PDF]

, 2015
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited.
Chan, Cecilia W. S, Kaplan, Warren, Khachigian, Levon M, Parish, Christopher   +3 more
core   +1 more source