miR‐30a‐5p inhibition promotes interaction of Fas+endothelial cells and FasL+microglia to decrease pathological neovascularization and promote physiological angiogenesis [PDF]
Glia, 2018 AbstractIschemia‐induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti‐VEGF agents but are not successful in all cases. In this study we determined that miR‐30a‐5p is another important mediator of retinal angiogenesis.
H. Maura Friedlander +12 more
openaire +3 more sources
An Egr-1 master switch for arteriogenesis: Studies in Egr-1 homozygous negative and wild-type animals [PDF]
, 2006 BackgroundArteriogenesis has been implicated as an important biologic response to acute vascular occlusion. The early growth response 1 (Egr-1) gene encodes an immediate-early response transcription factor that is upregulated by changes in vascular ...
Beckmann, James T. +8 more
core +1 more source
Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice [PDF]
, 2012 Endoplasmic reticulum (ER) stress and inflammation are important mechanisms that underlie many of the serious consequences of type II diabetes. However, the role of ER stress and inflammation in impaired ischaemia-induced neovascularization in type II ...
A. Amin +9 more
core +2 more sources
Investigative Opthalmology & Visual Science, 2005 To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization.C57BL/6 neonatal mice were reared in an 80% concentration of oxygen from postnatal day (P)7 to P12, followed by room-air breathing until P17, to induce ischemia-initiated ...
Yoshiaki Kubota +13 more
openaire +3 more sources
Intense Physiological Light Upregulates Vascular Endothelial Growth Factor and Enhances Choroidal Neovascularization via Peroxisome Proliferator-Activated Receptor γ Coactivator-1α in Mice [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 Objectives— Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear. Methods and Results— Effects of intense, but within physiological range, light on ...
Takahisa Furukawa +5 more
openaire +2 more sources
Erythropoietin Improves the Healing of Skin Necrosis Resulting From Doxorubicin Extravasation in a Rat Model [PDF]
, 2011 BackgroundDoxorubicin is an antineoplastic agent that causes skin necrosis when extravasated. Various agents have been tried to reduce tissue damage owing to extravasation.
Dündar, Emine +3 more
core +1 more source
Network Physiology reveals relations between network topology and physiological function [PDF]
Bashan, A. et al. Network Physiology reveals relations between
network topology and physiological function. Nature Communications 3:702 doi:
10.1038/ncomms1705 (2012), 2012 The human organism is an integrated network where complex physiologic systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge.
arxiv +1 more source
Matrix Metalloproteinases: Pro- and Anti-Angiogenic Activities [PDF]
, 2000 Matrix metalloproteinases (MMP) are a family of structurally related proteinases most widely recognized for their ability to degrade extracellular matrix, although recent investigations have demonstrated other biologic functions for these enzymes.
Cornelius, Lynn A., Raza, Saadia L.
core +1 more source
Acta Cirúrgica Brasileira, 2012 PURPOSE: To study the effects of the angico extract (Anadenanthera colubrina var. cebil) on the healing of rat skin. METHODS: Twenty adult rats were divided into four groups of five animals each, the G4, G7, G14 and G21, which corresponds to the ...
Wagner Soares Pessoa +6 more
doaj +1 more source
Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry. [PDF]
, 2019 To evaluate the association between a vessel size index (VSIMRI) derived from dynamic susceptibility contrast (DSC) perfusion imaging using a custom spin-and-gradient echo echoplanar imaging (SAGE-EPI) sequence and quantitative estimates of vessel ...
Chakhoyan, Ararat +13 more
core +2 more sources