PLoS ONE, 2011 Actin dynamics has emerged at the forefront of podocyte biology. Slit diaphragm junctional adhesion protein Nephrin is necessary for development of the podocyte morphology and transduces phosphorylation-dependent signals that regulate cytoskeletal ...
Madhusudan Venkatareddy +4 more
doaj +1 more source
Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes [PDF]
, 2015 Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS).
Alfano, Massimo +14 more
core +2 more sources
Advances in Biomarker Sciences and Technology, 2023 Background: Recombinant human erythropoietin (rHuEPO) is an effective treatment for renal anemia. Recently, there is evidence to suggest that rHuEPO may reduce podocyte injury in diabetic kidney disease (DKD).
Lingfeng Zeng +5 more
doaj +1 more source
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis. [PDF]
PLoS ONE, 2011 The assembly of specific synaptic connections represents a prime example of cellular recognition. Members of the Ig superfamily are among the most ancient proteins represented in the genomes of both mammalian and invertebrate organisms, where they ...
Nicola Wanner +5 more
doaj +1 more source
Kidney International Reports, 2018 Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome.
Nina A. van de Lest +6 more
doaj +1 more source
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. [PDF]
PLoS ONE, 2009 Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus.
Tomonori Hirose +9 more
doaj +1 more source
C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation [PDF]
, 2019 Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely ...
Ha, Tae-Sun +6 more
core +1 more source
A Compendium of Urinary Biomarkers Indicative of Glomerular Podocytopathy [PDF]
, 2013 It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte.
Pichler Sekulic, Simona +1 more
core +2 more sources
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. [PDF]
, 2008 The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation, '
Bader, Augustinus +16 more
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Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization [PDF]
Journal of Clinical Investigation, 2006 A properly established and maintained podocyte intercellular junction, or slit diaphragm, is a necessary component of the selective permeability barrier of the kidney glomerulus. The observation that mutation or deletion of the slit diaphragm transmembrane protein nephrin results in failure of podocyte foot process morphogenesis and concomitant ...
Rakesh, Verma +5 more
openaire +2 more sources