Results 41 to 50 of about 12,065 (211)

Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus.

PLoS ONE, 2018
Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation.
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Theodore Li, Joanna Kukla, Ashomathi Mollin, Gabriel Cara-Fuentes, Sanjeevkumar R Patel, Puneet Garg   +8 more
doaj   +1 more source

Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex [PDF]

BMB Reports, 2013
Nephrin, a structural molecule, is also a signaling molecule afterphosphorylation. Inhibition of nephrin phosphorylation iscorrelated with podocyte injury.
Dongqing Zha, Cheng Chen, Wei Liang, Xinghua Chen, Tean Ma, Hongxia Yang, Harry van Goor, Guohua Ding   +7 more
doaj   +1 more source

Nephrin – a biomarker of early glomerular injury [PDF]

Biomarker Research, 2014
Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part of podocytes, which-together with endothelial cells and the basement-form the glomerular filtration barrier.
Kandasamy, Yogavijayan, Smith, Roger, Lumbers, Eugenie R., Rudd, Donna   +3 more
openaire   +3 more sources

The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome. [PDF]

PLoS ONE, 2015
The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB).
Haiyan Wang, Zhihui Yue, Jinlang Wu, Ting Liu, Ying Mo, Xiaoyun Jiang, Liangzhong Sun   +6 more
doaj   +1 more source

Urolithins Modulate the Viability, Autophagy, Apoptosis, and Nephrin Turnover in Podocytes Exposed to High Glucose

Cells, 2022
Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid).
Milena Kotewicz, Mirosława Krauze-Baranowska, Agnieszka Daca, Agata Płoska, Sylwia Godlewska, Leszek Kalinowski, Barbara Lewko   +6 more
doaj   +1 more source

Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin [PDF]

, 2014
Nephrin and podocin are known to be closely related to the pharmacological effects of angiotensin-II receptor blocker (ARB). The objectives of this study were to investigate the role of nephrin and podocin using cisplatin-induced testicular damage and to
Alings, M., Bouwels, L., Cuijpers, P., Habibovic, M., Herrman, J. P., Pedersen, Susanne S., Theuns, D., Valk, S., van der Voort, P.   +8 more
core   +5 more sources

Expression of Nephrin in Pediatric Kidney Diseases [PDF]

Journal of the American Society of Nephrology, 2001
Abstract. Nephrin is a podocyte cell adhesion protein located at the slit diaphragm area of the kidney glomerulus. Mutations in the nephrin gene (NPHS1) lead to congenital nephrosis, suggesting that nephrin is essential for the glomerular filtration barrier.
Jaakko, Patrakka, Vesa, Ruotsalainen, Ilkka, Ketola, Christer, Holmberg, Markku, Heikinheimo, Karl, Tryggvason, Hannu, Jalanko   +6 more
openaire   +2 more sources

Modified Huangqi Chifeng Decoction Attenuates Proteinuria by Reducing Podocyte Injury in a Rat Model of Immunoglobulin a Nephropathy

Frontiers in Pharmacology, 2021
Modified Huangqi Chifeng decoction (MHCD) has been used to reduce proteinuria in immunoglobulin A nephropathy (IgAN) for many years. Previously, we have demonstrated its protective role in glomerular mesangial cells.
Meiying Chang, Bin Yang, Liusheng Li, Yuan Si, Mingming Zhao, Wei Hao, Jinning Zhao, Yu Zhang   +7 more
doaj   +1 more source

Characterization of novel glomerular proteins : role in physiology and disease [PDF]

, 2014
Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy.
Andersson, Ann-Charlotte
core   +1 more source

Anion Exchanger 1 Interacts with Nephrin in Podocytes [PDF]

Journal of the American Society of Nephrology, 2010
The central role of the multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaphragm is well established, but the mechanisms linking the slit diaphragm to the cytoskeleton and to the signaling pathways involved in maintaining the integrity of the glomerular filter remain incompletely understood.
Wu, F, Saleem, M.A, Kampik, N.B, Satchwell, T.J, Williamson, R.C, Blattner, S.M, Ni, L, Toth, T, White, G, Young, M.T, Parker, M.D, Alper, S.L, Wagner, C.A, Toye, A.M   +13 more
openaire   +4 more sources