Results 41 to 50 of about 12,068 (208)

Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation [PDF]

, 2014
Peer ...
Holmberg, Christer, Jalanko, Hannu
core   +1 more source

Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus.

PLoS ONE, 2018
Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation.
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Theodore Li, Joanna Kukla, Ashomathi Mollin, Gabriel Cara-Fuentes, Sanjeevkumar R Patel, Puneet Garg   +8 more
doaj   +1 more source

The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome. [PDF]

PLoS ONE, 2015
The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB).
Haiyan Wang, Zhihui Yue, Jinlang Wu, Ting Liu, Ying Mo, Xiaoyun Jiang, Liangzhong Sun   +6 more
doaj   +1 more source

Urolithins Modulate the Viability, Autophagy, Apoptosis, and Nephrin Turnover in Podocytes Exposed to High Glucose

Cells, 2022
Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid).
Milena Kotewicz, Mirosława Krauze-Baranowska, Agnieszka Daca, Agata Płoska, Sylwia Godlewska, Leszek Kalinowski, Barbara Lewko   +6 more
doaj   +1 more source

Normal levels of p27Xic1 are necessary for somite segmentation and determining pronephric organ size [PDF]

, 2009
The Xenopus laevis cyclin dependent kinase inhibitor p27Xic1 has been shown to be involved in exit from the cell cycle and differentiation of cells into a quiescent state in the nervous system, muscle tissue, heart and retina.
Anna Philpott, Barnett MW, Bassez T, Brändli AW, Carroll T, Chen J, Dale L, Daniels M, Di Cunto F, Elizabeth A. Jones, Greenwood J, Haldin CE, Hardcastle Z, Harland RM, Harlow E, Harris WA, Hartley RS, Jin X, Jones EA, Jones EA, Mauch TJ, Mitchell T, Moody SA, Movassagh M, Nguyen L, Nieuwkoop PD, Ohnuma S, Ohnuma S, Ozato K, Philpott A, Polyak K, Primmett DR, Reggiani L, Reynaud EG, Reynaud EG, Richard W. Naylor, Robert J. Collins, Saxén L, Seufert DW, Shou W, Snow MHL, Stern CD, Su JY, Thayer MJ, Vernon AE, Vernon AE, Vize PD, Wang Z, Zezula J   +48 more
core   +2 more sources

Nephrin – a biomarker of early glomerular injury [PDF]

Biomarker Research, 2014
Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part of podocytes, which-together with endothelial cells and the basement-form the glomerular filtration barrier.
Kandasamy, Yogavijayan, Smith, Roger, Lumbers, Eugenie R., Rudd, Donna   +3 more
openaire   +3 more sources

Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex [PDF]

BMB Reports, 2013
Nephrin, a structural molecule, is also a signaling molecule afterphosphorylation. Inhibition of nephrin phosphorylation iscorrelated with podocyte injury.
Dongqing Zha, Cheng Chen, Wei Liang, Xinghua Chen, Tean Ma, Hongxia Yang, Harry van Goor, Guohua Ding   +7 more
doaj   +1 more source

Modified Huangqi Chifeng Decoction Attenuates Proteinuria by Reducing Podocyte Injury in a Rat Model of Immunoglobulin a Nephropathy

Frontiers in Pharmacology, 2021
Modified Huangqi Chifeng decoction (MHCD) has been used to reduce proteinuria in immunoglobulin A nephropathy (IgAN) for many years. Previously, we have demonstrated its protective role in glomerular mesangial cells.
Meiying Chang, Bin Yang, Liusheng Li, Yuan Si, Mingming Zhao, Wei Hao, Jinning Zhao, Yu Zhang   +7 more
doaj   +1 more source

Human Myoblast and Mesenchymal Stem Cell Interactions Visualized by Videomicroscopy. [PDF]

, 2015
Muscle-derived progenitor cell (myoblast) therapy has promise for the treatment of denervated, weakened, and fibrotic muscle. The best methods for injecting myoblasts to promote fusion and retention have yet to be determined, however.
Belafsky, Peter C, Black, Amanda B, Dahlenburg, Heather, Kuhn, Maggie A, Nacey, Catherine, Nolta, Jan A, Pepper, Karen, Pontow, Suzanne   +7 more
core   +1 more source

Expression of Nephrin in Pediatric Kidney Diseases [PDF]

Journal of the American Society of Nephrology, 2001
Abstract. Nephrin is a podocyte cell adhesion protein located at the slit diaphragm area of the kidney glomerulus. Mutations in the nephrin gene (NPHS1) lead to congenital nephrosis, suggesting that nephrin is essential for the glomerular filtration barrier.
Jaakko, Patrakka, Vesa, Ruotsalainen, Ilkka, Ketola, Christer, Holmberg, Markku, Heikinheimo, Karl, Tryggvason, Hannu, Jalanko   +6 more
openaire   +2 more sources