APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway
Disease Models & Mechanisms, 2023 People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and APOL1-G2 risk
Jun-yi Zhu +5 more
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Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
eLife, 2022 The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
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JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease [PDF]
eLifeChronic kidney disease is a major health issue and is gaining prevalence. Using a Drosophila model for chronic kidney disease, we show that a high-fat diet (HFD) disrupts the slit diaphragm filtration structure in nephrocytes, the fly functional ...
Yunpo Zhao +4 more
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Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors [PDF]
Frontiers in Cell and Developmental Biology, 2022 The Drosophila lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes.
Ismaël Morin-Poulard +8 more
doaj +3 more sources
HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases
Disease Models & MechanismsPeople carrying two APOL1 risk alleles (RA) – G1 or G2 – are at greater risk of developing human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Jun-yi Zhu +6 more
doaj +3 more sources
Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. [PDF]
Cell Mol Life SciBlood ultrafiltration in nephrons critically depends on specialized intercellular junctions between podocytes, named slit diaphragms (SDs). Here, by studying a homologous structure found in Drosophila nephrocytes, we identify the phospholipid scramblase ...
Castillo-Mancho V +4 more
europepmc +5 more sources
Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage [PDF]
The EMBO JournalParaneoplastic syndrome represents severe and complex systemic clinical symptoms manifesting in multiple organs of cancer patients, but its cause and cellular underpinnings remain little explored.
Fei Cong +9 more
doaj +3 more sources
mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Dominik Spitz +6 more
doaj +2 more sources
Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage
Scientific Reports, 2021 Heart failure (HF) and the development of chronic kidney disease (CKD) have a direct association. Both can be cause and consequence of the other.
Estela Selma-Soriano +5 more
doaj +2 more sources
Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease. [PDF]
PLoS Biology, 2021 Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells ...
Aleksandra Lubojemska +8 more
doaj +2 more sources