Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
eLife, 2022 The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
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JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease [PDF]
eLifeChronic kidney disease is a major health issue and is gaining prevalence. Using a Drosophila model for chronic kidney disease, we show that a high-fat diet (HFD) disrupts the slit diaphragm filtration structure in nephrocytes, the fly functional ...
Yunpo Zhao +4 more
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mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Dominik Spitz +6 more
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Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Megan Delaney +4 more
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Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors [PDF]
Frontiers in Cell and Developmental Biology, 2022 The Drosophila lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes.
Ismaël Morin-Poulard +8 more
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Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes [PDF]
Scientific ReportsDue to their position on glomerular capillaries, podocytes are continuously counteracting biomechanical filtration forces. Most therapeutic interventions known to generally slow or prevent the progression of chronic kidney disease appear to lower these ...
Kristina Schulz +8 more
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Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease. [PDF]
PLoS Biology, 2021 Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells ...
Aleksandra Lubojemska +8 more
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Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity [PDF]
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
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Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage [PDF]
The EMBO JournalParaneoplastic syndrome represents severe and complex systemic clinical symptoms manifesting in multiple organs of cancer patients, but its cause and cellular underpinnings remain little explored.
Fei Cong +9 more
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Reconsidering protein quality: Role of amino acid composition in diet-induced hepatorenal stress [PDF]
Open Veterinary JournalRecent investigations into the physiological impact of diet on laboratory animals have brought renewed attention to the metabolic consequences of common dietary components.
Yves Hude, Yuxiao Hu
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