Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in Drosophila Nephrocytes [PDF]
CellsMitochondria are crucial for cellular ATP production. They are highly dynamic organelles, whose morphology and function are controlled through mitochondrial fusion and fission. The specific roles of mitochondria in podocytes, the highly specialized cells
Jun-yi Zhu +3 more
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dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity [PDF]
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
doaj +4 more sources
APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway
Disease Models & Mechanisms, 2023 ABSTRACT People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and APOL1-G2 risk alleles affect these cells through similar mechanisms.
Jun-yi Zhu +5 more
doaj +4 more sources
Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. [PDF]
PLoS ONE, 2015 Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised.
Jessica R Ivy +6 more
doaj +5 more sources
Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs [PDF]
Nature Communications, 2023 Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are ongoing.
Seong Kyu Han +15 more
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Using the Drosophila Nephrocyte to Model Podocyte Function and Disease [PDF]
Frontiers in Pediatrics, 2017 Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations ...
Martin Helmstädter +4 more
doaj +4 more sources
Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes. [PDF]
Kidney Int Rep, 2023 Genetic disorders are among the most prevalent causes leading to progressive glomerular disease and, ultimately, end-stage renal disease (ESRD) in children and adolescents. Identification of underlying genetic causes is indispensable for targeted treatment strategies and counseling of affected patients and their families.Here, we report on a boy who ...
Odenthal J +19 more
europepmc +5 more sources
HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases
Disease Models & MechanismsJun-yi Zhu +6 more
doaj +2 more sources
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes. [PDF]
Cell Biosci, 2023 Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of potential ...
Lee JG +6 more
europepmc +4 more sources