Tau reduction impairs nephrocyte function in Drosophila. [PDF]
BMB RepTau, a microtubule-associated protein, is known for its significant involvement in neurodegenerative diseases. While various molecular and immunohistochemical techniques have confirmed the presence of Tau in podocytes, its precise function within these ...
Lee J +6 more
europepmc +3 more sources
Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. [PDF]
PLoS ONE, 2015 Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised.
Jessica R Ivy +6 more
doaj +10 more sources
Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs [PDF]
Nature Communications, 2023 Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are ongoing.
Seong Kyu Han +15 more
doaj +4 more sources
Using the Drosophila Nephrocyte to Model Podocyte Function and Disease [PDF]
Frontiers in Pediatrics, 2017 Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations ...
Martin Helmstädter +4 more
doaj +5 more sources
Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in Drosophila Nephrocytes [PDF]
CellsMitochondria are crucial for cellular ATP production. They are highly dynamic organelles, whose morphology and function are controlled through mitochondrial fusion and fission. The specific roles of mitochondria in podocytes, the highly specialized cells
Jun-yi Zhu +3 more
doaj +4 more sources
dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity [PDF]
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
doaj +4 more sources
Drosophila Nephrocyte as a Model for Studying Glomerular Basement Membrane Physiology.
J Am Soc Nephrolvan de Leemput J, Han Z.
europepmc +4 more sources
Drosophila pericardial nephrocyte ultrastructure changes during ageing [PDF]
Mechanisms of Ageing and Development, 2018 Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial
O. Psathaki +3 more
semanticscholar +5 more sources
Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Megan Delaney +4 more
doaj +2 more sources
Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes [PDF]
Scientific ReportsDue to their position on glomerular capillaries, podocytes are continuously counteracting biomechanical filtration forces. Most therapeutic interventions known to generally slow or prevent the progression of chronic kidney disease appear to lower these ...
Kristina Schulz +8 more
doaj +2 more sources