Results 21 to 30 of about 1,206 (172)
Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity [PDF]
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
doaj +2 more sources
Modeling Podocyte Biology Using Drosophila Nephrocytes [PDF]
, 2019 Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier.
AH Brand +12 more
core +5 more sources
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm [PDF]
Nature, 2008 The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation, ‘
Helen Weavers +8 more
semanticscholar +6 more sources
Journal of Diabetes Research, 2020 Mesenchymal stem cells (MSCs) are shown to alleviate renal injury of diabetic nephropathy (DN) in rats. However, the underlying mechanism of this beneficial effect is not fully understood.
Lian Chen +7 more
doaj +2 more sources
Reconsidering protein quality: Role of amino acid composition in diet-induced hepatorenal stress [PDF]
Open Veterinary JournalRecent investigations into the physiological impact of diet on laboratory animals have brought renewed attention to the metabolic consequences of common dietary components.
Yves Hude, Yuxiao Hu
doaj +2 more sources
Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes [PDF]
Cell & Bioscience, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Luyao Wang +4 more
doaj +2 more sources
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function [PDF]
Nature Communications, 2019 Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of ...
J. A. Hurcombe +22 more
doaj +5 more sources
The Drosophila Nephrocyte - Modeling Podocyte Function and Disease [PDF]
, 2019 In modern industrialized nations, chronic non-communicable diseases have become the main reason of mortality. During the last years, the global health burden of chronic kidney diseases (CKD) has grown considerably and in many of these cases, no targeted ...
Hochapfel, Florian
core +3 more sources
Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes. [PDF]
Kidney Int Rep, 2023 Genetic disorders are among the most prevalent causes leading to progressive glomerular disease and, ultimately, end-stage renal disease (ESRD) in children and adolescents. Identification of underlying genetic causes is indispensable for targeted treatment strategies and counseling of affected patients and their families.Here, we report on a boy who ...
Odenthal J +19 more
europepmc +5 more sources