Results 41 to 50 of about 422 (124)
Cell & Bioscience, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Luyao Wang +4 more
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Cubilin and Amnionless Mediate Protein Reabsorption in Drosophila Nephrocytes [PDF]
Journal of the American Society of Nephrology, 2013 The insect nephrocyte and the mammalian glomerular podocyte are similar with regard to filtration, but it remains unclear whether there is an organ or cell type in flies that reabsorbs proteins. Here, we show that the Drosophila nephrocyte has molecular, structural, and functional similarities to the renal proximal tubule cell.
Fujian, Zhang +4 more
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Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage
Scientific Reports, 2021 Heart failure (HF) and the development of chronic kidney disease (CKD) have a direct association. Both can be cause and consequence of the other.
Estela Selma-Soriano +5 more
doaj +1 more source
Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila.
J Am Soc NephrolKey Points Piezo channels, known for detecting mechanical pressure, were found to be expressed at the lacuna channel membranes of nephrocytes.Piezo loss of function caused nephrocyte dysfunction, including disrupted slit diaphragm structure and altered lacuna channel morphology.Piezo deficiency
Zhao Y +5 more
europepmc +3 more sources
Disease Models & Mechanisms, 2020 Drosophila nephrocytes share functional, structural and molecular similarities with human podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex, and its expression is altered in mouse and human proteinuric disease ...
Estela Selma-Soriano +5 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 High alkalinity stress was considered as a major risk factor for aquatic animals surviving in saline-alkaline water. However, few information exists on the effects of alkalinity stress in crustacean species.
Qianqian Ge +3 more
doaj +1 more source
Filling the Gap: Drosophila Nephrocytes as Model System in Kidney Research [PDF]
Journal of the American Society of Nephrology, 2019 New and efficient sequencing technologies are constantly identifying novel gene variants in patients that may be the genetic cause of renal diseases. Recent studies show that, even for adult patients with CKD, monogenic causes can be detected in around 10% of patients.[1][1] Novel causative ...
Zvonimir, Marelja, Matias, Simons
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Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. [PDF]
Cell Mol Life SciAbstractBlood ultrafiltration in nephrons critically depends on specialized intercellular junctions between podocytes, named slit diaphragms (SDs). Here, by studying a homologous structure found in Drosophila nephrocytes, we identify the phospholipid scramblase Scramb1 as an essential component of the SD, uncovering a novel link between membrane ...
Castillo-Mancho V +4 more
europepmc +4 more sources
Біологія тварин, 2023 Principles of reptile treatment are significantly different from the drug therapy for mammals and birds, which is primarily due to anatomical and physiological peculiarities of reptiles.
R. S. Dankovych, V. I. Chuliuk
doaj +1 more source
APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death [PDF]
Journal of the American Society of Nephrology, 2016 People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of developing renal diseases. However, the mechanisms underlying APOL1-associated renal diseases are unknown. Because the APOL1 gene is unique to humans and some primates, new animal models are needed to understand the function of APOL1 in vivo.
Yulong, Fu +8 more
openaire +2 more sources