Results 51 to 60 of about 422 (124)

Drosophila Nephrocyte as a Model for Studying Glomerular Basement Membrane Physiology.

J Am Soc Nephrol
van de Leemput J, Han Z.
europepmc   +3 more sources

Histochemical research of cells functionally leading tissue liver and kidneys of rats after intravenous application of nanoparticles magnetite

Бюллетень сибирской медицины, 2011
After unitary and repeated intravenous application magnetite is shown their distribution in organism of a rat by method of magnetic resonance imaging. Accumulation of particles in a liver and a spleen of animals is shown.
I. V. Milto, I. V. Sukhodolo, T. K. Klimentiyeva, N. M. Shevtsova   +3 more
doaj   +1 more source

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Nature Communications, 2019
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of ...
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward   +22 more
doaj   +1 more source

Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte [PDF]

Journal of the American Society of Nephrology, 2016
Steroid-resistant nephrotic syndrome is characterized by podocyte dysfunction. Drosophila garland cell nephrocytes are podocyte-like cells and thus provide a potential in vivo model in which to study the pathogenesis of nephrotic syndrome. However, relevant pathomechanisms of nephrotic syndrome have not been studied in nephrocytes.
Hermle, Tobias, Braun, Daniela A., Helmstädter, Martin, Huber, Tobias B., Hildebrandt, Friedhelm   +4 more
openaire   +3 more sources

Single‐Cell Sequencing: A Sharp Sword for Deciphering Biological Innovations and Evolutionary Adaptations in Lower Vertebrates and Invertebrates

Reviews in Aquaculture, Volume 17, Issue 4, September 2025.
Single‐cell sequencing sheds light on cellular diversity, development, and immune evolution in fish and invertebrates, offering new insights into environmental adaptation and evolutionary biology. ABSTRACT Single‐cell sequencing (SCS) technology has revolutionized the study of cellular heterogeneity by enabling the exploration of biological processes ...
Chongbin Hu, Yun Hong, Lixin Xiang, Ye Chen, Jianzhong Shao, Hangjun Zhang   +5 more
wiley   +1 more source

Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Nephrocyte Injury and Proteinuria in a Diabetic Nephropathy Rat Model

Journal of Diabetes Research, 2020
Mesenchymal stem cells (MSCs) are shown to alleviate renal injury of diabetic nephropathy (DN) in rats. However, the underlying mechanism of this beneficial effect is not fully understood.
Lian Chen, E. Xiang, Changyong Li, Bing Han, Quan Zhang, Wei Rao, Cuihong Xiao, Dongcheng Wu   +7 more
doaj   +1 more source

On the Nephrocytes of Pediculus humanus

Parasitology, 1921
In Pediculus humanus are found two groups of excretory-accumulatory cells known as nephrocytes.The one group, the peri-oesophageal, lies ventrally and consists of large cells aggregated usually in two masses about the oesophagus anterior to the reniform salivary glands.The second group lies dorsally and consists of disseminated cell aggregates linked ...
George H. F. Nuttall, D. Keilin
openaire   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals

Cell Reports, 2015
Diabetic nephropathy is a major cause of end-stage kidney disease. Characterized by progressive microvascular disease, most efforts have focused on injury to the glomerular endothelium.
Jianbo Na, Mariya T. Sweetwyne, Ae Seo Deok Park, Katalin Susztak, Ross L. Cagan   +4 more
doaj   +1 more source

Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis

Disease Models & Mechanisms, 2020
Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure.
Wenjing Zheng, Karen Ocorr, Marc Tatar
doaj   +1 more source