Results 51 to 60 of about 1,206 (172)

Drosophila Filamin exhibits a mechano-protective role during nephrocyte injury via induction of hypertrophic growth

bioRxiv, 2021
Podocytes are highly specialized epithelial cells of the kidney glomerulus and are an essential part of the filtration barrier. Due to their position and function in the kidney, they are exposed to constant biomechanical forces such as shear stress and ...
Sybille Koehler, B. Denholm
semanticscholar   +1 more source

The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes: A Model of Vertebrate Podocytes [PDF]

, 2021
Kidney filtration of the blood requires specialized cells known as podocytes. Podocyte slit diaphragms (SDs) are intercellular junctions that contribute to size-selective filtration, which excludes larger proteins from the urine.
Mysh, Michael
core   +2 more sources

Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Podocyte lipid accumulation is a potential therapeutic target for diabetic nephropathy (DN). This study was aimed at clarifying the mechanism of Gandi capsule (GDC) ameliorating DN by regulating the lipid metabolism of podocytes. Network pharmacology methods were performed to screen the key molecules and potential targets of GDC for constructing the ...
Ying Zhang, Huijuan Yao, Chao Li, Wei Sun, Xiaofei Chen, Yan Cao, Yue Liu, Yan Liu, Jihui Chen, Jia Qi, Qiqiang Zhang, Hai Zhang, Ajing Xu, Jian Zhang, Valentina Pallottini   +14 more
wiley   +1 more source

Functional study of mammalian Neph proteins in Drosophila melanogaster. [PDF]

PLoS ONE, 2012
Neph molecules are highly conserved immunoglobulin superfamily proteins (IgSF) which are essential for multiple morphogenetic processes, including glomerular development in mammals and neuronal as well as nephrocyte development in D. melanogaster.
Martin Helmstädter, Kevin Lüthy, Markus Gödel, Matias Simons, Ashish, Deepak Nihalani, Stefan A Rensing, Karl-Friedrich Fischbach, Tobias B Huber   +8 more
doaj   +1 more source

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

Journal of Cellular and Molecular Medicine, Volume 25, Issue 23, Page 10798-10813, December 2021., 2021
Abstract Diabetic nephropathy (DN) remains one of the severe complications associated with diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits of human urine‐derived stem cells (hUSCs) in the treatment of DN. At present, the clinical benefits associated with hUSCs in the treatment of DN remains unclear.
Yu‐Rui Duan, Bao‐Ping Chen, Fang Chen, Su‐Xia Yang, Chao‐Yang Zhu, Ya‐Li Ma, Yang Li, Jun Shi   +7 more
wiley   +1 more source

ω‐3 Polyunsaturated Fatty Acids Facilitate the Repair of Peripheral Nerve Defects with Chemically Extracted Acellular Allograft in Rats

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Acellular allograft (ACA) improves the repair and reconstruction of long peripheral nerve defects. ω‐3 Polyunsaturated fatty acids (PUFAs) carry a neuroprotective potential, and their effects on ACA bridging were elucidated. Thirty rats with long gap sciatic nerve defects (15 mm long) were randomly divided into three groups (n = 10): ACA, ACA + PUFAs ...
Jun Zuo, Yuan Wu, Renkun Xiang, Zhiping Dai, Yi Zhu, Jafri Malin Abdullah   +5 more
wiley   +1 more source

Xianling Gubao Capsule Prevents Cadmium‐Induced Kidney Injury

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Xianling Gubao Capsule (XGC), a kind of capsule preparation of Chinese herbal officially approved for sale by the National Medical Products Administration (NMPA), has the effect of tonifying kidney and strengthening bones. Although the impact of XGC in treating bone diseases has been widely studied, the effect of XGC in kidney injury is unknown yet ...
Jian Huang, Xiao-tong Ma, Duo-duo Xu, Bao-jin Yao, Da-qing Zhao, Xiang-yang Leng, Jia Liu, Fatma M. El-Demerdash   +7 more
wiley   +1 more source

SPARC-Dependent Cardiomyopathy in Drosophila [PDF]

, 2016
Background—The Drosophila heart is an important model for studying the genetics underpinning mammalian cardiac function. The system comprises contractile cardiomyocytes, adjacent to which are pairs of highly endocytic pericardial nephrocytes that ...
Bodmer, R., Hartley, Paul S., Motamedchaboki, K., Ocorr, K.   +3 more
core   +1 more source

Mesenchymal Stem Cells: An Overview of Their Potential in Cell‐Based Therapy for Diabetic Nephropathy

Stem Cells International, Volume 2021, Issue 1, 2021., 2021
Diabetic nephropathy (DN) is a devastating complication associated with diabetes mellitus, and it is the leading cause of end‐stage renal diseases (ESRD). Over the last few decades, numerous studies have reported the beneficial effects of stem cell administration, specifically mesenchymal stem or stromal cells (MSCs), on tissue repair and regeneration.
Yan Wu, Chunlei Zhang, Ran Guo, Dan Wu, Jiayi Shi, Luxin Li, Yanhui Chu, Xiaohuan Yuan, Jie Gao, Adam Ye   +9 more
wiley   +1 more source

Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes.

J Am Soc Nephrol
Key Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in ...
Leroy C, Lang K, Spitz D, Milosavljevic J, Heinkele H, Kayser S, Helmstädter M, Walz G, Ulbrich MH, Hermle T.   +9 more
europepmc   +4 more sources