Results 101 to 110 of about 1,563,345 (405)

Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc

JOR Spine
Background Disc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of repetitive strikes loading on the biology and biomechanics of intervertebral discs (IVDs) using an organ culture model.
Jiaxiang Zhou, Jianmin Wang, Jianfeng Li, Zhengya Zhu, Zhongyuan He, Junhong Li, Tao Tang, Hongkun Chen, Yukun Du, Zhen Li, Manman Gao, Zhiyu Zhou, Yongming Xi   +12 more
doaj   +1 more source

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

eLife, 2020
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that ...
Ana Rita Costa, Sara C Sousa, Rita Pinto-Costa, José C Mateus, Cátia DF Lopes, Ana Catarina Costa, David Rosa, Diana Machado, Luis Pajuelo, Xuewei Wang, Feng-quan Zhou, António J Pereira, Paula Sampaio, Boris Y Rubinstein, Inês Mendes Pinto, Marko Lampe, Paulo Aguiar, Monica M Sousa   +17 more
doaj   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development

PLoS ONE, 2018
The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury.
Min Zhang, Qiang Zhou, Yuncin Luo, Tara Nguyen, M. Rosenblatt, V. Guaiquil   +5 more
semanticscholar   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

Rapid Sintering of Porous Organic Polymer Powders Into Mechanically Strong Monoliths for Efficient CO2 Capture

Advanced Functional Materials, EarlyView.
Spark plasma sintering enables rapid processing of porous organic polymer (POP) from fine powders to a freestanding and mechanically robust monolith. The sintering process retains the CO2 adsorption capacity and CO2/N2 selectivity, making the monolith more suitable as a solid sorbent for practical carbon capture applications.
Duan Li, Tianhui Shi, Sirui Ran, Lei Zeng, Chao Xu   +4 more
wiley   +1 more source

Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model

Frontiers in Physiology
IntroductionOssification of the posterior longitudinal ligaments (OPLL) is characterized by heterotopic ossification in the posterior longitudinal ligament of spine.
Tao Tang, Tao Tang, Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Fuan Wang, Lin Chen, Jianfeng Li, Hongkun Chen, Jiaxiang Zhou, Jianmin Wang, Shaoyu Liu, Yunfeng Yao, Xizhe Liu, Zhiyu Zhou   +15 more
doaj   +1 more source

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS [PDF]

, 2017
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here,
Apara, Akintomide, Ashouri, Masoumeh, Blackmore, Murray G., Brown, Dale P., Jr., Fernandes, Kimberly A., Galvao, Joana, Goldberg, Jeffrey L., Huang, Abigail, Iwao, Keiichiro, Kunzevitzky, Noelia J., Libby, Richard T., Moore, Darcie L., Nguyen, Tu, Shaw, Peter S., Trillo, Allison, Wang, Yan, Zhang, Ziong   +16 more
core   +2 more sources