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Nesprins in health and disease
Seminars in Cell & Developmental Biology, 2014LINC (Linker of Nucleoskeleton and Cytoskeleton) complex is an evolutionary conserved structure that spans the entire nuclear envelope (NE), and integrates the nuclear interior with the cytoskeleton, in order to support a diverse array of fundamental biological processes.
Sarah, Cartwright +1 more
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Nesprins LINC the nucleus and cytoskeleton
Current Opinion in Cell Biology, 2011Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors.
Mellad, Jason A. +2 more
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Methods in Molecular Biology, 2018
The biochemical characterization of proteins most often require their identification by immunoblotting. Whereas SDS-PAGE provides satisfactory results for most proteins, the identification of larger proteins requires alternative methods to ensure their separation and complete transfer onto nitrocellulose membranes.
Didier Hodzic
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The biochemical characterization of proteins most often require their identification by immunoblotting. Whereas SDS-PAGE provides satisfactory results for most proteins, the identification of larger proteins requires alternative methods to ensure their separation and complete transfer onto nitrocellulose membranes.
Didier Hodzic
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Nesprins in Cell Stability and Migration
2014Nesprins are a family of proteins that are primarily known for their localization along the nuclear envelope. Together with inner nuclear membrane SUN proteins, they form the core of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex that traverses both nuclear membranes to connect the cytoplasm and the nuclear interior.
Sascha, Neumann, Angelika A, Noegel
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Nesprin-2 mediated nuclear trafficking and its clinical implications [PDF]
Nucleus, 2015 Nuclear translocation of proteins has a crucial role in the pathogenesis of cancer, Alzheimer disease and viral infections. A complete understanding of nuclear trafficking mechanisms is therefore necessary in order to establish effective intervention strategies.
Angelika A. Noegel +2 more
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The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton
Biochemical Society Transactions, 2011Nesprins (nuclear envelope spectrin repeat proteins), also known as SYNE (synaptic nuclear envelope protein), MYNE (myocyte nuclear envelope protein), ENAPTIN and NUANCE, are proteins that are primarily components of the nuclear envelope. The nuclear envelope is a continuous membrane system composed of two lipid bilayers: an inner and an outer nuclear ...
Angelika A, Noegel, Sascha, Neumann
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Nesprin isoforms: are they inside or outside the nucleus?
Biochemical Society Transactions, 2010The giant isoforms of nesprins 1 and 2 are emerging as important players in cellular organization, particularly in the positioning of nuclei, and possibly other organelles, within the cytoplasm. The experimental evidence suggests that nesprins also occur at the inner nuclear membrane, where they interact with the nuclear lamina.
Glenn E, Morris, K Natalie, Randles
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Nesprin-3: a versatile connector between the nucleus and the cytoskeleton
Biochemical Society Transactions, 2011The cytoskeleton is connected to the nuclear interior by LINC (linker of nucleoskeleton and cytoskeleton) complexes located in the nuclear envelope. These complexes consist of SUN proteins and nesprins present in the inner and outer nuclear membrane respectively.
Mirjam, Ketema, Arnoud, Sonnenberg
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Mechanical Responses of the Giant Nesprin-2
Abstract The nesprin protein family serves as a critical physical bridge between the cytoskeleton–a fundamental structural scaffold and mechanotransduction hub of the cell, and the nucleus–an intriguing and emerging mechano-responsive element.Fei Shang +7 more
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Analysis of Nesprin-2 Interaction with Its Binding Partners and Actin
2018Nuclei are connected to the actin cytoskeleton for controlling its position in the cell and for mechanochemical signaling. Nesprin-2G is one of the major outer nuclear membrane proteins that links the nucleus to the actin cytoskeleton. In addition to its paired calponin homology (CH) domains, nesprin-2G interacts with actin filaments by binding the ...
Susumu, Antoku, Gregg G, Gundersen
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