Results 101 to 110 of about 97,228 (263)
International Journal of Cancer, EarlyView.Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer +11 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2014 Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease and a public health problem. Therefore, rapid detection and management is important.
Mohammad Kargar +3 more
doaj
Nested-PCR for detection of Brucella in milk
浙江大学学报. 农业与生命科学版, 2008 To detect Brucella inflection in milk, a nested-PCR assay was developed by designing outward-directed and inward-directed primers for omp25, omp31 and 16S rRNA genes of Brucella abortus, and optimizing the extraction of Brucella genomic DNA. The results show that two rounds of amplification with the two pairs of synthesized primers F4/R2 and F2D/R1U ...
DU Zhen-kun +4 more
openaire +1 more source
International Journal of Cancer, EarlyView.Plasmid‐like DNA sequences frequently found in bovine milk and serum have been proposed as infectious agents promoting indirect carcinogenesis. This multi‐omics study detected immune cells positive for these bovine meat and milk factors (BMMFs) in patients with lung cancer, with BMMF expression inversely correlated with smoking intensity.
Nives Cecere +17 more
wiley +1 more source
Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function
iMetaOmics, EarlyView.During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Hao Zhang +11 more
wiley +1 more source
Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling
Interdisciplinary Medicine, EarlyView.Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang +3 more
wiley +1 more source
Journal of Clinical Psychology, EarlyView.ABSTRACT Objectives The “helping alliance” between patients, caregivers, and healthcare professionals (HCPs) plays an important role in the evaluation of therapeutic interventions. The aim of this study was to develop a German version of the Helping Alliance Questionnaire for pediatric patients (HAQ‐P) and caregivers (HAQ‐CG). Methods The questionnaire
Lisa‐Marie Rau +2 more
wiley +1 more source
Gut function among children treated for severe acute malnutrition: A cohort study in Uganda
JPGN Reports, EarlyView.Abstract Objectives Impaired gut function in children with severe acute malnutrition (SAM) is associated with morbidity. We aimed to assess changes in six biomarkers representing different domains of gut function among children with complicated SAM during nutritional rehabilitation, and to identify predictors of these changes.
Betty Lanyero +12 more
wiley +1 more source
Borrelia and Genital Lichen Sclerosus: A Critical Review of the Evidence
JEADV Clinical Practice, EarlyView.ABSTRACT Background Lichen sclerosus (LSc) is a chronic inflammatory dermatosis that primarily affects the genitalia. Growing evidence supports chronic occlusive urine exposure as the principal pathogenic driver, though other mechanisms, including mechanical irritation, hormonal influences, autoimmunity, and infection, have been proposed.
Liang Zhi Wong +4 more
wiley +1 more source
New Plant Protection, EarlyView.We developed a transient expression system for sugarcane using Guitang 42 culm, suitable for various assays such as GCaMP6‐based calcium imaging. This system revealed that ScNCED3 acts as an early drought response signal, positively regulated by ScPYL4‐12, ScOST1‐12, and ScMPK6‐11.
Dianqi Wu +10 more
wiley +1 more source