Results 121 to 130 of about 4,546,897 (298)

Investigating the Effects of Long-Term Fine Particulate Matter Exposure on Autism Spectrum Disorder Severity: Evidence from Multiple Analytical Approaches

Toxics
With rapid industrial expansion, air pollution’s adverse neurological effects have gained increasing attention. Children face a greater risk of neurological damage because of their higher breathing rates, developing brains, and limited ability to ...
Jianrui Dou, Kaiyue Zhang, Ruijin Xie, Hua Xu, Qiyang Pan, Xue Xiao, Yufan Luo, Shengjie Xu, Wei Xiao, Dongqin Wu, Bing Wang, Linpei Zhang, Chenyu Sun, Yueying Liu   +13 more
doaj   +1 more source

toxicology (34)

Toxicology Presentation slides: 1.25% carbon monoxide, test results print ...

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Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Role of KMT2C in per- and polyfluoroalkyl substances induced liver cancer: A network toxicology and Mendelian randomization analysis

环境与职业医学
BackgroundPer- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants widely distributed in the environment. Epidemiological studies have shown that PFAS exposure is closely associated with liver dysfunction and an increased risk of ...
Nan OUYANG, Wei XU, Feng DONG, Ze ZHU, Xiaoqiong WU   +4 more
doaj   +1 more source

toxicology (51)

Toxicology Presentation slides: rat study with rat ...

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SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Measuring the toxicological ramifications of MNP exposure on skin senescence: Insights gained through network toxicology and transcriptomic analysis

Ecotoxicology and Environmental Safety
Micro(nano) plastics (MNPs) are ubiquitous environmental pollutants with systemic toxicity to humans. As the primary barrier of the body, the skin is directly exposed to MNPs; however, the mechanisms underlying MNP-induced dermal toxicity remain unclear.
Zexin, Zhang, Yiwen, Deng, Jianguo, Chen, Cong, Li, Xinyue, Dai, Changchen, Wang, Pengfei, Sun, Shu, Li, Haiyue, Jiang, Bo, Pan   +9 more
openaire   +2 more sources

toxicology (41)

Toxicology Presentation slides: electrode placement with ...

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Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

toxicology (10)

Toxicology Presentation slides: Head Blood Flow versus Altitude.

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