Results 111 to 120 of about 4,546,897 (298)

Network toxicology reveals glyphosate mechanisms in kidney injury and cancer​​

Scientific Reports
Abstract Molecular mechanisms underlying glyphosate-induced nephrotoxicity and carcinogenicity were investigated through integrated network toxicology, molecular docking, and dynamics simulations. Screening identified 47 potential glyphosate targets; intersection analysis yielded 20 kidney injury and 31 kidney cancer shared targets.
Dong, Yiling, Zhu, Jufan
openaire   +2 more sources

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Network toxicology reveals mechanisms of Endosulfan-induced lung injury

Inhalation Toxicology
Endosulfan, an organochlorine pesticide, consists of two isomers (α-Endosulfan and β-Endosulfan) and a primary metabolite, Endosulfan sulfate (END-SO4). Due to its pervasive environmental contamination and harmful effects—such as neurotoxicity, endocrine disruption, and reproductive toxicity in humans—END was included in the Stockholm Convention on ...
Fuat, Karakuş, Burak, Kuzu
openaire   +2 more sources

toxicology (13)

Toxicology Presentation slides: test results print ...

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Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Network Toxicology and Molecular Docking to Elucidate the Mechanisms of Intestinal Toxicity Induced by P-Phenylenediamine Antioxidants and Their Quinone Derivatives

Toxics
P-phenylenediamines (PPDs) and their quinone derivatives (PPDQs), emerging pollutants widespread in urban environments, exhibit biotoxicological risks.
Hui Zou, Yumei Tan, Xiyi Ren, Zhu Li, Yongxiang Liu   +4 more
doaj   +1 more source

Unraveling the toxicological impact of Bisphenol A exposure on dermatomyositis: An integration of network toxicology and machine learning approaches

PLOS One
Background Dermatomyositis is a common immune-mediated skin disorder whose pathogenesis has not been fully elucidated. Environmental factors play a key role in its onset and progression. Bisphenol A (BPA) is a widespread environmental pollutant known to pose risks to human health. Previous studies have indicated
Lili Cheng, Zhongfu Tang, Ming Li, Chuanbing Huang   +3 more
openaire   +2 more sources

toxicology (58)

Toxicology Presentation slides: Gas Concentration ...

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FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Toxicology in the Middle Ages and Renaissance

, 2017
Toxicology in the Middle Ages and Renaissance provides an authoritative and fascinating exploration into the use of toxins and poisons in the Middle Ages and Renaissance. Part of the History of Toxicology and Environmental Health series, this volume is a

core   +1 more source