Results 101 to 110 of about 4,546,897 (298)

Iberoamerican of Toxicology and Chemical Safety Network

, 2013
Peer ...
Font, G., Lafuente, A., Herrero, Oscar, Pillco, Araceli, Cavieres, Fernanda, Gutiérrez, R., Escalante, P., Peña de Torres, Eduardo de la   +7 more
openaire   +1 more source

The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach

Toxicology Research
Abstract Background Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.
Yongji Li, Geqiang Wang, Peiran Liu, Lin Zhang, Hai Hu, Xiangjun Yang, Hongpeng Liu   +6 more
openaire   +2 more sources

toxicology (5)

Toxicology Presentation slides: signs and symptoms at various concentrations of ...

core  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Investigating the Potential Effects of 6PPDQ on Prostate Cancer Through Network Toxicology and Molecular Docking

Toxics
(1) Background: N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), as a newly discovered environmental toxin, has been found more frequently in our living conditions.
Yuanzhi Song, Wuhong Weng, Shengde Wu
doaj   +1 more source

toxicology (57)

Toxicology Presentation slides: image of a rat within a cage for ...

core  

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

A case-control study identifying critical exposure windows in the association between ambient air pollution and spontaneous abortion

Scientific Reports
To examine associations between early-pregnancy exposure to ambient air pollutants and spontaneous abortion (SA), identify lag windows using distributed lag non-linear models (DLNM), and explore the potential mechanisms via network toxicology. A hospital-
Yingying Zhang, Zhiwei Zou, Haonan Dai, Leyao Wang, Jie Wang, Wen Sun, Hui Wang, Qingqing Dong, Wenlin Bai, Ruiling Fang, Yue Zhang, Ping Zhang, Wenping Zhang, Wenxia Song, Lijian Lei   +14 more
doaj   +1 more source

Impact of a Nanoscale Iron–Chlorobenzene Mixture on Pulmonary Injury in Rat Pups: Extending Exposure Knowledge Using Network Technology

Toxics
Particulate matter coexists with persistent organic pollutants (POPs) in the atmosphere, which can enter the human body by accompanying inhalable particles in the respiratory tract.
Kezhou Liu, Ying Xu, Mengjie Ying, Meiling Chen   +3 more
doaj   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source