Results 81 to 90 of about 4,546,897 (298)

Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization

CPT: Pharmacometrics & Systems Pharmacology
Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning ...
Zhijun Xie, Hang Lei, Pengcheng Zhang, Zhi Li, Wenfu Tang   +4 more
doaj   +1 more source

Integrating network toxicology， molecular docking， and molecular dynamics simulation to explore the mechanisms underlying depression induced by low‑chlorinated polychlorinated dibenzo‑p‑dioxins

Sichuan jingshen weisheng
BackgroundPolychlorinated dibenzo‑p‑dioxins （PCDDs） is a type of global environmental pollutants， have been shown in numerous studies to exert neurotoxic effects.
Yin Xueting, Chu Boyi, Yang Pengzhan, Zhang Chengpeng   +3 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Integrating network toxicology, transcriptomics, and metabolomics uncovers the hepatotoxic mechanisms of okadaic acid in LO2 cells

Ecotoxicology and Environmental Safety
Okadaic acid (OKA), a potent phycotoxin existed in shellfish, is known to cause liver damage. However, the hepatic mechanisms underlying its toxicity remain poorly understood.
Zhiqiang Luo, Fulu Pan, Huixia Fan, Ruofan Guo, Jingqi Zheng, Shuo Zhang, Jiaru Shi, Wei Lin, Chen Wang, Yanli Pan, Guohua Yu   +10 more
doaj   +1 more source

Structural improvement of higher education in environmental toxicology in Latin America and Europe

, 2000
Industrial development has resulted in an increased release of chemicals and other agents into the environment, resulting in damage to the environment as well as increasing the risk of adverse effects on human health. Environmental toxicology (ET) is the
Dekant, W., Fowler, J., Jaramillo-Juárez, F., Kingi, L. J., Albores, A., Barril-Antuña, J., Diaz-Barriga, F., Manno, M., Cebrián, M. E., Torres-Alanı́s, O., Gil, L., Olarte, G., Patño, R. I., Ostrosky-Wegman, P., De Matteis, F.   +14 more
core   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Network Iberoamerican Toxicology and Chemical Safety

, 2015
Peer ...
Ruiz, M.J., Jos, MA., Herrero, Oscar, Pillco, Araceli, Escalante, P., Cavieres, Fernanda, Gutiérrez, R., Font, G., Peña de Torres, Eduardo de la   +8 more
openaire   +1 more source

toxicology (11)

Toxicology Presentation slides: Schematic.

core