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An Undergraduate Toxicology Seminar Focusing on Ethical Reasoning and Communication Skill Development [PDF]

, 2020
The development of an undergraduate major in toxicology at Nazareth College provided the opportunity to develop a one-credit Principles of Toxicology Seminar designed to address ethical reasoning skills and communication (both oral and written), areas ...
Zamule, Stephanie
core  

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Comments/clarifications to the publication by Xin et al. (2025)

Ecotoxicology and Environmental Safety
Xin et al. (2025) try to apply New Approach Methodologies (NAMs) for hazard identification and risk assessment using DINCH (cyclohexane-1,2-dicarboxylic acid, diisononyl ester, CAS Reg No 166412-78-8) as a model substance.
R. Otter, A. Langsch, P. Harmon, R. David   +3 more
doaj   +1 more source

toxicology (12)

Toxicology Presentation slides: Altitude versus Time of Useful ...

core  

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach

BMC Medicine
Background Tranexamic acid, an antifibrinolytic drug, is effective for surgical hemostasis and bleeding-related disorders but may induce neurotoxicity, such as epilepsy. The mechanisms driving TXA-induced epilepsy remain poorly understood, as traditional
Tianyang Chen, Dalong Liu, Yan Gu, Tianqi Gao, Xiaojiang Li, XiangYang Leng   +5 more
doaj   +1 more source

Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking

Toxicology Mechanisms and Methods
Pyrethroids (PYs), a class of insecticides widely used in agricultural and household pest control, have been reported to trigger neurological damage. However, the underlying mechanisms of toxicity remain unclear. In this study, we applied a network toxicology approach to identify the core targets and signaling pathways associated with the pathogenesis ...
Yuting, Lin, Wenqi, Zeng, Yang, Zhang, Yanghui, Hu, Zhonghan, Liang, Zhixing, Chen, Zhuoying, Lu, Weien, Zhang, Zhenjie, Wang, Yanling, Jiang, Mingyu, Chen, Haining, Ma, Yikuan, Du, Chunling, Ma, Chun, Yang   +14 more
openaire   +2 more sources

toxicology (61)

Toxicology Presentation slides: unidentified test results print ...

core  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Metabolomic Profiling and Network Toxicology: Mechanistic Insights into Effect of Gossypol Acetate Isomers in Uterine Fibroids and Liver Injury

Pharmaceuticals
Objective: Gossypol is a natural polyphenolic dialdehyde product that is primarily isolated from cottonseed. It is a racemized mixture of (−)-gossypol and (+)-gossypol that has anti-infection, antimalarial, antiviral, antifertility, antitumor and ...
Zishuo Liu, Hui Zhang, Jun Yao
doaj   +1 more source