Results 181 to 190 of about 4,454 (194)

Specific Detection of Neu5Gc in Animal Tissues by Immunohistochemistry

2020
One of the major obstacles in xenotransplantation is tissue expression of the non-human mammalian carbohydrate N-glycolylneuraminic acid (Neu5Gc). This 9-carbon backbone acidic sugar is the hydroxylated form of N-acetylneuraminic acid (Neu5Ac), and both constitute the two most common sialic acid types in mammals. Loss of CMP-Neu5Ac hydroxylase encoding
Anu, Paul, Shirley, Bachar Abramovitch, Vered, Padler-Karavani   +2 more
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Preparation of lauryl thioglycoside of N-glycolylneuraminic acid (Neu5Gc) as a useful glycosyl donor for assembly of an oligosaccharide containing Neu5Gc

Tetrahedron Letters, 2021
Abstract Efficient synthesis of lauryl thioglycoside of Neu5Gc was accomplished from a known thioglycoside of Neu5Ac. The reactivities of the Neu5Gc thioglycoside for O-glycosidation by means of TMSOTf-NIS as a promoter system were investigated, and the thioglycoside showed good activities with simple alcohols. In addition to the simple alcohols, the
Jianhong Zhang, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano, Koji Matsuoka   +4 more
openaire   +1 more source

Neu5Gc (N-Glycolylneuraminic Acid)

2020
Among a group of SAs, NeuAc and NeuGc are two of the most common derivatives. SA biosynthesis begins at the cytosol and the synthesized SA is converted to activated nucleotide saccharide form in the nucleus. The activated SA is delivered to Golgi apparatus for ST reaction. STs add SA residues to the terminal sugars of the glycolipids, especially of the
openaire   +1 more source

Immune disguise: the mechanisms of Neu5Gc inducing autoimmune and transplant rejection

Genes & Immunity, 2022
Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc (N-hydroxyacetylneuraminic acid) is a pathogenic non-human sialic acid, which is very similar to the molecular structure of Neu5Ac (N-acetylneuraminic acid) in human body.
Fadian Ding, Yunfeng Lin, Guozhong Liu, Yuxin Liu, Feng Gao, Qicai Liu, Zhibo Zhang, Shangeng Weng   +7 more
openaire   +2 more sources

Incorporation of the Non-Human Sialic Acid Neu5Gc into Human Leukemic Cells and Targeting by Natural Human Anti-Neu5Gc Antibodies.

Blood, 2004
Abstract Humans are incapable of synthesizing the common mammalian cell surface sialic acid N-glycolylneuraminic acid (Neu5Gc), due to an irreversible genetic mutation that occurred after our last common ancestor with great apes. Despite this, we found trace levels of Neu5Gc in certain normal human tissues, and higher levels in fetal and
Dzung H. Nguyen, Pam Tangvoranuntakul, Ajit Varki   +2 more
openaire   +1 more source

Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation

Genes & Immunity
Repeated implantation failure (RIF) is one of the most prominent problems in the field of assisted reproduction. Neu5Gc on the surface of decidual macrophages (dMΦ) leads to different activation patterns of dMΦ, which affects embryo implantation and development.
Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai   +5 more
openaire   +2 more sources

Generation of recombinant anti-N-glycolylneuraminic acid (Neu5Gc) scFv and its applications for detection and quantitation of Neu5Gc

2016
Sialic acids are a family of 9 carbon α-keto acid monosaccharides. Owing to their terminal position on glycans, sialic acids are involved in cell adhesion and recognition events, host pathogen interactions, immune regulation and in disease processes such as cancer progression.
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Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans

Carbohydrate Research, 2009
Efficient sialylations using N-glycolylneuraminic acid (Neu5Gc) phosphite donors having an acetyl or benzyl group on the glycolyl moiety are described in the synthesis of Neu5Gc-containing glycans. Both phosphite donors 1 and 2 were readily coupled with primary and secondary acceptor alcohols in propionitrile at -78 degrees C to provide the desired ...
Shinya, Hanashima, Taku, Tomiya, Daichi, Ishikawa, Shoji, Akai, Ken-ichi, Sato   +4 more
openaire   +2 more sources

Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome

Xenotransplantation, 2019
AbstractHumans cannot synthesize N‐glycolylneuraminic acid (Neu5Gc) but dietary Neu5Gc can be absorbed and deposited on endothelial cells (ECs) and diet‐induced anti‐Neu5Gc antibodies (Abs) develop early in human life. While the interaction of Neu5Gc and diet‐induced anti‐Neu5Gc Abs occurs in all normal individuals, endothelium activation by elicited ...
Le Berre, Ludmilla, Danger, Richard, Mai, Hoa, Amon, Ron, Leviatan Ben‐arye, Shani, Bruneau, Sarah, Sénage, Thomas, Perreault, Hélène, Teraiya, Milan, Nguyen, Thi van Ha, Le Tourneau, Thierry, Yu, Hai, Chen, Xi, Galli, Cesare, Roussel, Jean-Christian, Mañez, Rafael, Costa, Cristina, Brouard, Sophie, Galiñanes, Manuel, Harris, Kristina, Gitelman, Stephen, Cozzi, Emanuele, Charreau, Béatrice, Padler‐karavani, Vered, Soulillou, Jean‐paul   +24 more
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Synthesis of Neu5Ac- and Neu5Gc-α-(2→6′)-lactosamine 3-aminopropyl glycosides

Carbohydrate Research, 2001
In order to prepare 3-aminopropyl glycosides of Neu5Ac-alpha-(2-->6')-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-alpha-(2-->6')-lactosamine 2, a series of lactosamine acceptors with two, three, and four free OH groups in the galactose residue was studied in glycosylations with a conventional sialyl donor phenyl [methyl 5-
A A, Sherman, O N, Yudina, A S, Shashkov, V M, Menshov, N E, Nifant'ev   +4 more
openaire   +2 more sources